Recent advances in the identification of the host factors involved in dengue virus replication
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Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.
Keywordsdengue virus (DENV) host factors replication proteins miRNAs
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This work was supported by the National Natural Science Foundation of China (81371794) and Guangdong Natural Science Foundation (2014A030311007).
- Huerta V, Toledo P, Fleitas N, Martin A, Pupo D, Yero A, Sarria M, Sanchez A, Besada V, Ramos Y, Marquez G, Guirola O, Chinea G. 2014. Receptor-activated human alpha2-macroglobulin interacts with the envelope protein of dengue virus and protects virions from temperature-induced inactivation through multivalent binding. J Gen Virol, 95: 2668–2676.CrossRefPubMedGoogle Scholar
- Marques RE, Guabiraba R, Del Sarto JL, Rocha RF, Queiroz AL, Cisalpino D, Marques PE, Pacca CC, Fagundes CT, Menezes GB, Nogueira ML, Souza DG, Teixeira MM. 2015. Dengue virus requires the CC-chemokine receptor CCR5 for replication and infection development. Immunology, 145: 583–596.CrossRefPubMedPubMedCentralGoogle Scholar
- Michael JI, Salvatore Vp. 1981. Clearance and Binding of Two Electrophoretic “Fast” Forms of Human a2-Macroglobulin. J Biol Chem, 256: 8134–8139.Google Scholar
- Perreira JM, Aker AM, Savidis G, Chin CR, McDougall WM, Portmann JM, Meraner P, Smith MC, Rahman M, Baker RE, Gauthier A, Franti M, Brass AL. 2015. RNASEK Is a V-ATP ase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus. Cell Rep, 12: 850–863.CrossRefPubMedGoogle Scholar
- Ramaen O, Joubert A, Simister P, Belgareh-Touze N, Olivares-Sanchez MC, Zeeh JC, Chantalat S, Golinelli-Cohen MP, Jackson CL, Biou V, Cherfils J. 2007. Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors. J Biol Chem, 282: 28834–28842.CrossRefPubMedGoogle Scholar
- Repeke CE, Ferreira SB, Jr., Claudino M, Silveira EM, de Assis GF, Avila-Campos MJ, Silva JS, Garlet GP. 2010. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice. Bone, 46: 1122–1130.CrossRefPubMedGoogle Scholar
- Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL. 2016. Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell Rep, 16: 232–246.CrossRefPubMedGoogle Scholar
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