Virologica Sinica

, Volume 32, Issue 1, pp 23–31 | Cite as

Recent advances in the identification of the host factors involved in dengue virus replication

  • Yi Wang
  • Ping ZhangEmail author


Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.


dengue virus (DENV) host factors replication proteins miRNAs 


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This work was supported by the National Natural Science Foundation of China (81371794) and Guangdong Natural Science Foundation (2014A030311007).


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Copyright information

© Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2017

Authors and Affiliations

  1. 1.Department of Immunology, Institute of Human Virology, Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina
  2. 2.Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)Ministry of EducationGuangzhouChina

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