Virologica Sinica

, Volume 32, Issue 1, pp 63–72 | Cite as

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

  • Geng Li
  • Pan Pan
  • Qiuyan He
  • Xiujuan Kong
  • Kailang Wu
  • Wei Zhang
  • Yuntao Liu
  • Huiting Huang
  • Jianbo Liu
  • Zhongde Zhang
  • De Wu
  • Xiaoping Lai
  • Xiaohong Liu
  • Jianguo Wu
Open Access
Research article

Abstract

The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou.

Keywords

dengue virus (DENV) phylogenetic analysis envelope (E) gene enzootic transmission cycle 

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Copyright information

© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative commons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Geng Li
    • 1
    • 2
  • Pan Pan
    • 2
  • Qiuyan He
    • 1
  • Xiujuan Kong
    • 1
  • Kailang Wu
    • 2
  • Wei Zhang
    • 1
    • 2
  • Yuntao Liu
    • 4
  • Huiting Huang
    • 3
  • Jianbo Liu
    • 3
  • Zhongde Zhang
    • 4
  • De Wu
    • 5
  • Xiaoping Lai
    • 1
  • Xiaohong Liu
    • 1
    • 3
  • Jianguo Wu
    • 1
    • 2
  1. 1.School of Chinese Meterla MedicaGuangzhou University of Chinese MedicineGuangzhouChina
  2. 2.State Key Laboratory of Virology, College of Life SciencesWuhan UniversityWuhanChina
  3. 3.The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina
  4. 4.Guangdong Province Traditional Chinese Medical HospitalGuangzhouChina
  5. 5.Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina

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