Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus
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Recent outbreaks of Zika virus (ZIKV) infections in Oceania's islands and the Americas were characterized by high numbers of cases and the spread of the virus to new areas. To better understand the origin of ZIKV, its epidemic history was reviewed. Although the available records and information are limited, two major genetic lineages of ZIKV were identified in previous studies. However, in this study, three lineages were identified based on a phylogenetic analysis of all virus sequences from GenBank, including those of the envelope protein (E) and non-structural protein 5 (NS5) coding regions. The spatial and temporal distributions of the three identified ZIKV lineages and the recombination events and mechanisms underlying their divergence and evolution were further elaborated. The potential migration pathway of ZIKV was also characterized. Our findings revealed the central roles of two African countries, Senegal and Cote d'Ivoire, in ZIKV evolution and genotypic divergence. Furthermore, our results suggested that the outbreaks in Asia and the Pacific islands originated from Africa. The results provide insights into the geographic origins of ZIKV outbreaks and the spread of the virus, and also contribute to a better understanding of ZIKV evolution, which is important for the prevention and control of ZIKV infections.
KeywordsFlaviviridae Zika virus (ZIKV) phylogenetic analysis lineages recombination migration
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- Alera MT, Hermann L, Tac-An IA, Klungthong C, Rutvisuttinunt W, Manasatienkij W, Villa D, Thaisomboonsuk B, Velasco JM, Chinnawirotpisan P, Lago CB, Roque VG, Jr., Macareo LR, Srikiatkhachorn A, Fernandez S, Yoon IK. 2015. Zika virus infection, Philippines, 2012. Emerg Infect Dis, 21: 722–724.PubMedGoogle Scholar
- Baronti C, Piorkowski G, Charrel RN, Boubis L, Leparc-Goffart I, de Lamballerie X. 2014. Complete coding sequence of zika virus from a French polynesia outbreak in 2013. Genome Announc, 2.Google Scholar
- Buathong R, Hermann L, Thaisomboonsuk B, Rutvisuttinunt W, Klungthong C, Chinnawirotpisan P, Manasatienkij W, Nisalak A, Fernandez S, Yoon IK, Akrasewi P, Plipat T. 2015. Detection of Zika Virus Infection in Thailand, 2012–2014. Am J Trop Med Hyg, 93: 380–383.CrossRefPubMedPubMedCentralGoogle Scholar
- Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, Pretrick M, Marfel M, Holzbauer S, Dubray C, Guillaumot L, Griggs A, Bel M, Lambert AJ, Laven J, Kosoy O, Panella A, Biggerstaff BJ, Fischer M, Hayes EB. 2009. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med, 360: 2536–2543.PubMedGoogle Scholar
- Fonseca K, Meatherall B, Zarra D, Drebot M, MacDonald J, Pabbaraju K, Wong S, Webster P, Lindsay R, Tellier R. 2014. First case of Zika virus infection in a returning Canadian traveler. Am J Trop Med Hyg, 91: 1035–1038.Google Scholar
- Kindhauser MK, Allen T, Frank V, Santhana RS, Dye C. 2016. Zika: the origin and spread of a mosquito-borne virus. Bull World Health Organ.Google Scholar
- Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, Baudouin L, Mallet H, Musso D, Ghawche F. 2014. Zika virus infection complicated by Guillain-Barre syndrome—case report, French Polynesia, December 2013. Euro Surveill, 19.Google Scholar
- Roth A, Mercier A, Lepers C, Hoy D, Duituturaga S, Benyon E, Guillaumot L, Souares Y. 2014. Concurrent outbreaks of dengue, chikungunya and Zika virus infections -an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012–2014. Euro Surveill, 19.Google Scholar
- World Health Organization. 2014. A global brief on vector-borne diseases.Google Scholar
- Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Gunther S, Oestereich L, Cadar D, Munoz-Fontela C, Bartoloni A, Schmidt-Chanasit J. 2015. Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications. J Clin Virol, 63: 32–35.PubMedGoogle Scholar