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Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines

Virologica Sinica volume 31, pages 110–117 (2016)Cite this article

Abstract

An effective vaccine for human immunodeficiency virus (HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome (AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.

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  1. Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China

    Zhenyuan Wang, Chunjun Qin, Jing Hu, Xiaoqiang Guo & Jian Yin

  2. Wuxi Medical School, Jiangnan University, Wuxi, 214122, China

    Jing Hu

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  1. Zhenyuan Wang
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Wang, Z., Qin, C., Hu, J. et al. Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines. Virol. Sin. 31, 110–117 (2016). https://doi.org/10.1007/s12250-015-3691-3

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Keywords

  • vaccine
  • human immunodeficiency virus (HIV)
  • glycoprotein
  • N-glycosylation
  • neutralizing antibodies