Virologica Sinica

, Volume 30, Issue 5, pp 326–343 | Cite as

Dengue epidemiology and pathogenesis: images of the future viewed through a mirror of the past

  • Rashedul Islam
  • Mohammed Salahuddin
  • Md. Salahuddin Ayubi
  • Tahmina Hossain
  • Apurba Majumder
  • Andrew W. Taylor-Robinson
  • Abdullah Mahmud-Al-Rafat


Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.


dengue epidemiology pathogenesis dengue vaccine vector control anti-viral animal model 


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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Rashedul Islam
    • 1
  • Mohammed Salahuddin
    • 1
  • Md. Salahuddin Ayubi
    • 1
  • Tahmina Hossain
    • 1
  • Apurba Majumder
    • 2
  • Andrew W. Taylor-Robinson
    • 3
  • Abdullah Mahmud-Al-Rafat
    • 2
    • 4
  1. 1.Bio-Resources Technology and Industrial Biotechnology Laboratory, Department of Biotechnology and Genetic EngineeringJahangirnagar UniversityDhakaBangladesh
  2. 2.Biotechnology and Genetic Engineering DisciplineKhulna UniversityKhulnaBangladesh
  3. 3.School of Medical & Applied SciencesCentral Queensland UniversityRockhamptonAustralia
  4. 4.Research and Development (R&D) DepartmentIncepta Vaccine LimitedZirabo, Savar, DhakaBangladesh

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