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Recent advances in the study of Kaposi’s sarcoma-associated herpesvirus replication and pathogenesis

Virologica Sinica volume 30, pages 130–145 (2015)Cite this article

Abstract

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi’s sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi’s sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.

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  1. Department of Biological Science, Florida State University, Tallahassee, 32306, USA

    Denis Avey, Brittany Brewers & Fanxiu Zhu

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  1. Denis Avey
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Avey, D., Brewers, B. & Zhu, F. Recent advances in the study of Kaposi’s sarcoma-associated herpesvirus replication and pathogenesis. Virol. Sin. 30, 130–145 (2015). https://doi.org/10.1007/s12250-015-3595-2

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Keywords

  • Kaposi’s sarcoma-associated herpesvirus (KSHV)
  • Kaposi’s sarcoma
  • epigenetic
  • epigenome
  • herpesvirus
  • oncovirus
  • chromatin