Virologica Sinica

, Volume 30, Issue 2, pp 130–145 | Cite as

Recent advances in the study of Kaposi’s sarcoma-associated herpesvirus replication and pathogenesis

  • Denis Avey
  • Brittany Brewers
  • Fanxiu Zhu


It has now been over twenty years since a novel herpesviral genome was identified in Kaposi’s sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi’s sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.


Kaposi’s sarcoma-associated herpesvirus (KSHV) Kaposi’s sarcoma epigenetic epigenome herpesvirus oncovirus chromatin 


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© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biological ScienceFlorida State UniversityTallahasseeUSA

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