Virologica Sinica

, Volume 30, Issue 2, pp 146–152 | Cite as

EV71 infection correlates with viral IgG preexisting at pharyngo-laryngeal mucosa in children

  • Jingchang Xue
  • Yaoming LiEmail author
  • Xiaoyi Xu
  • Jie Yu
  • Hu Yan
  • Huimin Yan
Research Article


Enterovirus 71 (EV71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. Clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. Mucosa, especially epithelium of alimentary canal, was considered the primary site of EV71 infection. It has been elusive whether the preexsiting viral antibody in mucosa plays a role in EV71 infection. To answer this question, we respectively measured viral antibody response and EV71 RNA copy number of one hundred throat swab specimens from clinically confirmed EV71-infected children. The results released that low-level of mucosal IgG antibody against EV71 broadly existed in young population. More importantly, it further elucidated that the children with mucosal preexsiting EV71 IgG were prone to be infected, which suggested a former viral IgG mediated enhancement of viral infection in vivo.


EV71 clinical infection mucosal IgG VP1 VP2 3D 


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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jingchang Xue
    • 2
  • Yaoming Li
    • 1
    Email author
  • Xiaoyi Xu
    • 2
  • Jie Yu
    • 1
  • Hu Yan
    • 1
  • Huimin Yan
    • 1
  1. 1.Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina
  2. 2.Changzhou Center for Disease Control and PreventionChangzhouChina

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