Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae
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The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally (inter-strain) and vertically (cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of V. cholerae, the study of the lysogenic phage CTXΦ has attracted much attention. Based on the progress of current research, the genomic features and their arrangement, the host-dependent regulatory mechanisms of CTXΦ phage survival, proliferation and propagation were reviewed to further understand the phage’s role in the evolutionary and epidemiological mechanisms of V. cholerae.
KeywordsVibrio cholerae lysogenic bacteriophage CTXΦ regulation evolution
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- Bhattacharya T, Chatterjee S, Maiti D, Bhadra R K, Takeda Y, Nair G B, Nandy R K. 2006. Molecular analysis of the rstR and orfU genes of the CTX prophages integrated in the small chromosomes of environmental Vibrio cholerae non-O1, non-O139 strains. Environ Microbiol, 8: 52 6–634.CrossRefGoogle Scholar
- Biao K. 1999. Ph.D. thesis. Structure of the Genome of Lysogenic Bacteriophage CTXphi Without Cholera Toxin Gene and Function of its RS Region. Institute of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine, Beijing.Google Scholar
- Biao K, Liu Y Q, Qi G M, Zhang L J, Gao S Y. 2002. Clone and Analysis of CTXphi Prophage Genome which not Carrying Toxin Gene of Vibrio cholerae. Acta Microbiologica Sinica, 42:573–581. (In Chinese)Google Scholar
- Heidelberg J F, Eisen J A, Nelson W C, Clayton R A, Gwinn M L, Dodson R J, Haft D H, Hickey E K, Peterson J D, Umayam L, Gill S R, Nelson K E, Read T D, Tettelin H, Richardson D, Ermolaeva M D, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann R D, Nierman W C, White O, Salzberg S L, Smith H O, Colwell R R, Mekalanos J J, Venter J C, Fraser C M. 2000. DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature, 406: 477–483.CrossRefPubMedGoogle Scholar
- Kan B, Qi G M, Liu Y Q, Liu C L, Gao S Y. 1999. Genome of bacteriophage CTXφ without the presence of ctxAB exists in ctxAB? strains of Vibrio cholerae. Chin J Microb Immunol, 19: 175–179. (In Chinese)Google Scholar
- Li F, Du P, Li B, Ke C, Chen A, Chen J, Zhou H, Li J, Morris J G, Jr., Kan B, Wang D. 2014. Distribution of virulence-associated genes and genetic relationships in non-O1/O139 Vibrio cholerae aquatic isolates from China. Appl Environ Microbiol, 80: 4987–4992.CrossRefPubMedCentralPubMedGoogle Scholar
- Liu G W, Yan M Y, Qi G M, Gao S Y, Kan B. 2005. study on infection of different strains Vibrio cholerae O1 by El tor CTXphi. Acta Microbiologica Sinica, 45: 758–762. (In Chinese)Google Scholar
- Nair G B, Faruque S M, Bhuiyan N A, Kamruzzaman M, Siddique A K, Sack D A. 2002. New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh. J Clin Microbiol, 40: 3296–3299.CrossRefPubMedCentralPubMedGoogle Scholar