Virologica Sinica

, Volume 28, Issue 6, pp 315–317 | Cite as

Bats as animal reservoirs for the SARS coronavirus: Hypothesis proved after 10 years of virus hunting

  • Manli Wang
  • Zhihong HuEmail author


Recently, the team led by Dr. Zhengli Shi from Wuhan Institute of Virology, Chinese Academy of Sciences, and Dr. Peter Daszak from Ecohealth Alliance identified SL-CoVs in Chinese horseshoe bats that were 95% identical to human SARS-CoV and were able to use human angiotensin-converting enzyme 2 (ACE2) receptor for docking and entry. Remarkably, they isolated the first known live bat SL-CoV that replicates in human and related cells. Their findings provide clear evidence that some SL-CoVs circulating in bats are capable of infecting and replicating in human (Ge X Y, et al., 2013).


Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome Middle East Respiratory Syndrome Receptor Binding Domain Wuhan Institute 
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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina

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