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Virologica Sinica

, Volume 28, Issue 6, pp 318–325 | Cite as

High-resolution 3D structures reveal the biological functions of reoviruses

  • Xiaoming Li
  • Qin Fang
Review

Abstract

Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies have focused on high-resolution three-dimensional structures of reovirus particles by using cryo-electron microscopy (cryo-EM) to approach the resolutions seen in X-ray crystallographic structures. The results of cryo-EM image reconstructions allow tracing of most of the protein side chains, and thus permit integration of structural and functional information into a coherent mechanism for reovirus assembly and entry.

Keywords

Non-enveloped virus Reoviruses Structural basis Assembly Cell entry 

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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina
  2. 2.School of Basic Medical SciencesWuhan UniversityWuhanChina

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