Virologica Sinica

, Volume 28, Issue 4, pp 193–201

Crimean-Congo hemorrhagic fever: An overview


DOI: 10.1007/s12250-013-3327-4

Cite this article as:
Öncü, S. Virol. Sin. (2013) 28: 193. doi:10.1007/s12250-013-3327-4


Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral infection that is a serious threat to humans. The disease is widely distributed in Africa, Asia, and Europe and has developed into a serious public health concern. Humans become infected through the bites of ticks, by contact with a patient with CCHF, or by contact with blood or tissues from viremic livestock. Microvascular instability and impaired hemostasis are the hallmarks of the infection. Infection in human begins with nonspecific febrile symptoms, but may progress to a serious hemorrhagic syndrome with high mortality rates. Enzyme-linked immunoassay (ELISA) and polymerase chain reaction (PCR) are the most used and specific tests for the diagnosis. The mainstay of treatment is supportive. Although definitive studies are not available, ribavirin is suggested to be effective especially at the earlier phase of the infection. Uses of universal protective measures are the best way to avoid the infection. In this review, all aspects of CCHF are overviewed in light of the current literature.


Crimean-Congo Hemorrhagic Fever Epidemiology Transmission Pathogenesis Diagnosis Treatment Prevention 


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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Infectious Diseases and Clinical MicrobiologyAdnan Menderes University Medical FacultyAydinTurkey

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