Characterization of a putative filovirus vaccine: Virus-like particles
- First Online:
Filoviruses are hemorrhagic fever viruses endemic to parts of Africa and the Philippines. Infection carries with it a mortality rate of up to 90% and currently there are no effective vaccines or therapeutics available to combat infection. However, the filovirus virus-like particles (VLP), which are currently under development, have been shown to be a promising vaccine candidate. They provide protection from infection in the mouse, guinea pig, and nonhuman primate models of infection, eliciting high anti-glycoprotein antibody titers and T cell responses to viral proteins. In this review, we will highlight the development of the filovirus VLP and describe the current understanding of VLP immunogenicity and correlates of protection.
KeywordsFilovirus Ebola Marburg Vaccine Virus-like particle Correlates of Protection
Unable to display preview. Download preview PDF.
- World Health Organization. 2012a. Outbreak news. Ebola, Democratic Republic of the Congo. Wkly Epidemiol Rec, 87: 421.Google Scholar
- World Health Organization. 2012b. Outbreak news. Marburg haemorrhagic fever, Uganda. Wkly Epidemiol Rec, 87: 414.Google Scholar
- Bosio C M, Aman M J, Grogan C, Hogan R, Ruthel G, Negley D, Mohamadzadeh M, Bavari S, and Schmaljohn A. 2003. Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation. J Infect Dis, 188: 1630–1638.PubMedCrossRefGoogle Scholar
- Wahl-Jensen V, Kurz S, Feldmann F, Buehler L K, Kindrachuk J, DeFilippis V, da Silva Correia J, Fruh K, Kuhn J H, Burton D R, and Feldmann H. 2011. Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression. PLoS Negl Trop Dis, 5: e1359.PubMedCrossRefGoogle Scholar
- Warfield K L, Posten N A, Swenson D L, Olinger G G, Esposito D, Gillette W K, Hopkins R F, Costantino J, Panchal R G, Hartley J L, Aman M J, and Bavari S. 2007. Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents. J Infect Dis, 196Suppl 2: S421–429.PubMedCrossRefGoogle Scholar