Virologica Sinica

, Volume 28, Issue 1, pp 3–15 | Cite as

An overview of the highly pathogenic H5N1 influenza virus

  • Jingchuan Yin
  • Shi Liu
  • Ying ZhuEmail author


Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.


Avian influenza H5N1 Transmission Virulence Pathogenesis 


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© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.The State Key laboratory of Virology and College of Life SciencesWuhan UniversityWuhanChina

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