Virologica Sinica

, Volume 26, Issue 6, pp 357–365 | Cite as

Ribosome inactivating proteins from plants inhibiting viruses

Article

Abstract

Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and herpes simplex virus (HSV). Most of the research work related to RIPs has been focused on antiviral activity against HIV; however, the exact mechanism of antiviral activity is still not clear. The mechanism of antiviral activity was thought to follow inactivation of the host cell ribosome, leading to inhibition of viral protein translation and host cell death. Enzymatic activity of RIPs is not limited to depurination of the large rRNA, in addition they can depurinate viral DNA as well as RNA. Recently, Phase I/II clinical trials have demonstrated the potential use of RIPs for treating patients with HIV disease. The aim of this review is to focus on various RIPs from plants associated with anti-HIV activity.

Key words

Ribosome inactivating protein Human immunodeficiency virus Hepatitis B virus Herpes simplex virus 

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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Centre for Biotechnology and Interdisciplinary Science (BioDeakin), Institute of Technology Research and Innovation (ITRI)Deakin UniversityVictoriaAustralia
  2. 2.Protein and Fermentation Biotechnology Laboratory, Department of BiotechnologyPunjabi UniversityPatialaIndia
  3. 3.Department of BotanyPunjabi UniversityPatialaIndia

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