Large DNA viruses normally have complex structures with many of protein components derived from both viral and host origins. The development in proteomics, especially mass spectrometry identification techniques provide powerful tools for analyzing large viruses. In this review, we have summarized the recent achievements on proteomic studies of large DNA viruses, such as herpesvirus, poxvirus, nimavirus and baculoviruse. The proteomics of baculovirus occlusion-derived virions (ODV) were emphasized. Different mass spectrometry techniques used on various baculoviruses were introduced, and the identified structurally associated proteins of baculoviruses are summarized.
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Foundation items: The grants of National Science Foundation of China (30630002, 30670078); 973 Program (2009CB118903); Programme Strategic Scientific Alliances between China and the Netherlands (2008AA000238).
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Wang, Rr., Hu, Zh., Wang, Hl. et al. Virion proteomics of large DNA viruses. Virol. Sin. 24, 268–284 (2009). https://doi.org/10.1007/s12250-009-3062-z
- Virion proteomics
- Large DNA viruses