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Functional analyses of mammalian reovirus nonstructural protein μNS


Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein μNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that μNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly.

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Correspondence to Qin Fang.

Additional information

Foundation items: National Basic Research Program of China (973 Program) (2009CB118701); National Natural Scientific Foundation of China (30671615, 30871940); Innovation project of the Chinese Academy of Sciences (KSCX2-YW-N-021 to QF).

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Fan, C., Fang, Q. Functional analyses of mammalian reovirus nonstructural protein μNS. Virol. Sin. 24, 1–8 (2009).

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Key words

  • dsRNA virus
  • Mammalian orthoreoviruses
  • Nonstructural protein μNS

CLC number

  • Q786