Virologica Sinica

, Volume 24, Issue 1, pp 1–8 | Cite as

Functional analyses of mammalian reovirus nonstructural protein μNS

  • Chao Fan
  • Qin FangEmail author


Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein μNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that μNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly.

Key words

dsRNA virus Mammalian orthoreoviruses Nonstructural protein μNS 

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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag GmbH 2009

Authors and Affiliations

  1. 1.State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina
  2. 2.Graduate School of the Chinese Academy of SciencesBeijingChina

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