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Current status of natural products from plants as anti-herpes simplex virus 1 agents


Nucleoside analogues have been the mainstay of clinical treatment of herpes simplex virus 1 (HSV-1) infections since their development. However, the emergence of drug resistant strains has underlined the urgency of the discovery of novel anti-HSV-1 drugs. Natural products, which provided many novel drug leads, are known to be an important source of anti-HSV-1 agents. Herein, we present an overview of natural products with anti-HSV-1 activities isolated from a variety of plants reported in recent years. Several different compounds, mainly belonging to the three groups of polysaccharides, polyphenols and terpenes, showed antiviral effects against HSV-1, indicating their potential to be promising anti-HSV-1 agents.

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Corresponding author

Correspondence to Yi-fei Wang.

Additional information

Foundation item: Joint funds of National Natural Science Foundation of China (U0632010)

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Xiang, Yf., Pei, Y. & Wang, Yf. Current status of natural products from plants as anti-herpes simplex virus 1 agents. Virol. Sin. 23, 305 (2008).

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Key words

  • Herpes simplex virus 1 (HSV-1)
  • Antiviral
  • Anti-HSV-1
  • Natural product

CLC number

  • R93