Virologica Sinica

, Volume 23, Issue 3, pp 226–231 | Cite as

Expression of human papillomavirus in mammary carcinoma and its possible mechanism in carcinogenesis

  • Chun-ling Fan
  • Jing-hua Zhou
  • Cheng-yi Hu


To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS, P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma (P<0.05). The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.

Key words

Mammary carcinoma Human papillomavirus (HPV) Inducible nitric oxide synthase P53 protein Human telomerase reverse transciptase 

CLC number



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Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag GmbH 2008

Authors and Affiliations

  1. 1.Heilongjiang August-first Land-Reclamation UniversityDaqingChina
  2. 2.Heilongjiang Chinese Medical UniversityHarbinChina
  3. 3.The 4th Hospital of Harbin Medical University HarbinHarbinChina

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