Abstract
Purpose
The present study reports synthesis, characterization and in vitro evaluation of physicochemical and biological properties of dendritic lipopeptide oligomers comprising L-glutamic acid dendrons and myristoyl tails such that termini of the molecules carry carboxylic ester, carboxylic acid or alcohol functions, which account for nonpolar neutral, polar anionic and polar neutral surfaces, respectively.
Methods
Reactions adopted in the current work were fairly rapid, moderately simplified and required fewer coupling reagents. As inherent physicochemical and biological properties depend upon structural details, synthesized compounds were tested for the presence of foaming, nanoparticle formation, antibacterial and anticancer potential, if any.
Results
The synthesized nonpolar molecule demonstrated potential to form self-assembled polymeric nanoparticles, whereas the polar molecules demonstrated surfactant-like properties. None of the synthesized molecules demonstrated any inherent antibacterial activity against gram-positive as well as gram-negative bacterial strains, but compound with hydroxyl termini showed anticancer activity hint as a result of preliminary screening.
Conclusion
The synthesized molecules demonstrate potential for their application as drug delivery materials and hold scope for further investigations.
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Acknowledgements
The authors are thankful to the institute Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS University for providing comprehensive research facilities.
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Hegde, N., Juvale, K. & Prabhakar, B. Synthesis and In Vitro Evaluation of Inherent Properties of L-Glutamic Acid Based Dendritic Lipopeptide Oligomers. J Pharm Innov 17, 228–236 (2022). https://doi.org/10.1007/s12247-020-09493-7
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DOI: https://doi.org/10.1007/s12247-020-09493-7