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Development and Evaluation of In Situ Gel of Silver Sulfadiazine for Improved Therapeutic Efficacy Against Infectious Burn Wound

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Abstract

Purpose

Less local availability and higher skin permeation restrict wide application of silver sulfadiazine (SSD) formulations against infectious burn wound.

Aim

We aimed to develop β-cyclodextrin inclusion complex-based in situ pluronic gel of SSD (β-CD-ssd P-Gel).

Methods

Formation of inclusion complex was confirmed by FT-IR, DSC, SEM, and XRD and checked for improved solubility.

Results and Discussion

Poloxamer (407/118)-based in situ gel of inclusion complex was prepared and characterized for its gelation temperature (33.50 °C), viscosity (1159.25 ± 5.60 cps), pH (6.4 ± 0.56), and drug content (91.56 ± 1.62%). The developed gel showed slow drug release and slow permeation of the drug through the skin. It showed broader zone of Staphylococcus aureus growth inhibition (31 ± 0.20 mm) and high wound contraction (98.89%) when compared with the marketed formulation (26 ± 0.20 mm and 58.00%, respectively).

Conclusions

A consistent, biocompatible, β-CD-ssd P-Gel was prepared successfully. It was found able to ensure increased local availability by forming viscous gel below body temperature, high SSD availability at the desired site, and high efficacy against infectious wound.

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Acknowledgments

Authors are thankful to the management of ISF College of Pharmacy for providing institutional scholar’s fund, necessary infrastructure, and facilities to complete this work. We acknowledge Mr. Anand Rai for helping us out with technical and editorial improvements.

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Authors and Affiliations

  1. Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, 142001, India

    Navin Joshi, Neeraj Mishra & Vineet Kumar Rai

  2. Amity Institute of Pharmacy, Amity Unversity Madhya Pradesh, Gwalior, MP, India

    Neeraj Mishra

Authors
  1. Navin Joshi
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  2. Neeraj Mishra
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  3. Vineet Kumar Rai
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Correspondence to Vineet Kumar Rai.

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Joshi, N., Mishra, N. & Rai, V.K. Development and Evaluation of In Situ Gel of Silver Sulfadiazine for Improved Therapeutic Efficacy Against Infectious Burn Wound. J Pharm Innov 16, 537–550 (2021). https://doi.org/10.1007/s12247-020-09464-y

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