Abstract
Staphylococcus aureus is a serious threat to public health. S. aureus infection can cause acute or long-term persistent infections that are often resistant to antibiotics and are associated with high morbidity and death. Understanding the defensive systems of S. aureus can help clinicians make the best use of antimicrobial drugs and can also help with antimicrobial stewardship. The mechanisms and clinical implications of S. aureus defense systems, as well as potential response systems, were discussed in this study. Because resistance to all currently available antibiotics is unavoidable, new medicines are always being developed. Alternative techniques, such as anti-virulence and bacteriophage therapies, are being researched and may become major tools in the fight against staphylococcal infections in the future, in addition to the development of new small compounds that affect cell viability.
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This work was supported by the National Natural Science Foundation of China under Grant number 81973105 and Key Scientific Research Project of Henan Institution of Higher Education under Grant number 21A330008. The funders have no role in the data collection, data analysis, preparation of manuscript, and decision to submission.
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Guangcai Duan and Haiyan Yang contributed to the study conception and design. Hongjie Hou and Yang Li performed search. Hongjie Hou, Yuefei Jin, Shuaiyin Chen, and Jinzhao Long contributed new methods and models. The first draft of the manuscript was written by Hongjie Hou and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Hou, H., Li, Y., Jin, Y. et al. The crafty opponent: the defense systems of Staphylococcus aureus and response measures. Folia Microbiol 67, 233–243 (2022). https://doi.org/10.1007/s12223-022-00954-9
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DOI: https://doi.org/10.1007/s12223-022-00954-9