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Shigella flexneri: an emerging pathogen

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Abstract

Shigella flexneri is a leading etiologic agent of diarrhea in low socioeconomic countries. Notably, various serotypes in S. flexneri are reported from different regions of the world. The precise approximations of illness and death owing to shigellosis are missing in low socioeconomic countries, although it is widespread in different regions. The inadequate statistics available reveal S. flexneri to be a significant food and waterborne pathogen. All over the world, different antibiotic-resistant strains of S. flexneri serotypes have been emerged especially multidrug-resistant strains. Recently, increased resistance was observed in cephalosporins (3rd generation), azithromycin, and fluoroquinolones. There is a need for a continuous surveillance study on antibiotic resistance that will be helpful in the update of the antibiogram. The shigellosis burden can be reduced by adopting preventive measures like delivery of safe drinking water, suitable sanitation, and development of an effective and inexpensive multivalent vaccine. This review attempts to provide the recent findings of S. flexneri related to epidemiology and the emergence of multidrug resistance.

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References

  • Abu-elyazeed RR, Wierzba TF, Frenck RW et al (2004) Epidemiology of Shigella-associated diarrhea in rural Egyptian children. Am J Trop Med Hyg 71:367–372

    PubMed  Google Scholar 

  • Ahmed K, Shakoori FR, Shakoori AR (2003) Aetiology of shigellosis in Northern Pakistan. J Health Popul Nutr 21:32–39

    PubMed  Google Scholar 

  • Ahmed SF, Riddle MS, Wierzba TF et al (2006) Epidemiology and genetic characterization of Shigella flexneri strains isolated from three paediatric populations in Egypt (2000–2004). Epidemiol Infect 134:1237

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ahmed B, Shakoori FR, Ali SS, Shakoori AR (2009) Antimicrobial resistance and plasmid profile analysis of clinically isolated Shigella dysenteriae in Azad Kashmir, Pakistan. Pak J Zool 41:495–503

    CAS  Google Scholar 

  • Ahmed OB, Omar AO, Asghar AH, Elhassan MM (2013) Prevalence of TEM, SHV and CTX-M genes in Escherichia coli and Klebsiella spp urinary isolates from Sudan with confirmed ESBL phenotype. Life Sci J 10:191–195

    Google Scholar 

  • Ahmed D, Ud-Din AIMS, Wahid SUH et al (2014) Emergence of blaTEM type extended-Spectrum β-lactamase producing Salmonella spp. in the urban area of Bangladesh. ISRN Microbiol 2014:1–3

    CAS  Google Scholar 

  • Allison GE, Verma NK (2000) Serotype-converting bacteriophages and O-antigen modification in Shigella flexneri. Trends Microbiol 8:17–23

    CAS  PubMed  Google Scholar 

  • Anandan S, Sethuvel MDP, Gajendiren RV, Walia KVB (2017) Molecular characterization of antimicrobial resistance in clinical Shigella isolates during 2014 and 2015: trends in South India. Germs 7:115–122

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ashkenazi S, Cohen D (2013) An update on vaccines against Shigella. Ther Adv Vaccines 1:113–123

    PubMed  PubMed Central  Google Scholar 

  • Bannister BA, Gillespie SH (2006) Gastrointestinal infections and food poisoning. Infection: microbiology and management, 3rd edn, Oxford, pp 167–201

  • Bardhan P, Faruque ASG, Naheed A, Sack DA (2010) Decrease in shigellosis-related deaths without Shigella spp. specific interventions, Asia. Emerg Infect Dis 16:1718–1723

    PubMed  PubMed Central  Google Scholar 

  • Barman S, Chatterjee S, Chowdhury G, Ramamurthy T, Niyogi SK, Kumar R, Koley H (2010) Plasmid-mediated streptomycin and sulfamethoxazole resistance in Shigella flexneri 3a. Int J Antimicrob Agents 36:348–351

    CAS  PubMed  Google Scholar 

  • Barthelem M, Peduzzi J, Labia R (1985) Distinction between the primary structures of TEM-1 and TEM-2 beta-lactamases. Ann Inst Pasteur Microbiol 136:311–321

    Google Scholar 

  • Ben Sallem R, Ben Slama K, Rojo-Bezares B, Porres-Osante N, Jouini A, Klibi N, Boudabous A, Sáenz Y, Torres C (2014) IncI1 plasmids carrying bla(CTX-M-1) or bla(CMY-2) genes in Escherichia coli from healthy humans and animals in Tunisia. Microb Drug Resist 20:495–500

    CAS  PubMed  Google Scholar 

  • Bhattacharya S, Khanal B, Bhattarai NR et al (2005) Prevalence of Shigella species and their antimicrobial resistance patterns in Eastern Nepal. J Health Popul Nutr 23:339–342

    PubMed  Google Scholar 

  • Bhattacharya D, Bhattacharya H, Thamizhmani R, Sayi DS, Reesu R, Anwesh M, Kartick C, Bharadwaj AP, Singhania M, Sugunan AP, Roy S (2014) Shigellosis in Bay of Bengal islands, India: clinical and seasonal patterns, surveillance of antibiotic susceptibility patterns, and molecular characterization of multidrug-resistant Shigella strains isolated during a 6-year period from 2006 to 2011. Eur J Clin Microbiol Infect Dis 33:157–170

    CAS  PubMed  Google Scholar 

  • Blair JMA, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ (2015) Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol 13:42–51

    CAS  PubMed  Google Scholar 

  • Bradford PA (2001) Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 14:933–951

    CAS  PubMed  PubMed Central  Google Scholar 

  • Brooks JT, Shapiro RL, Kumar L, Wells JG, Phillips-Howard PA, Shi YP, Vulule JM, Hoekstra RM, Mintz E, Slutsker L (2003) Epidemiology of sporadic bloody diarrhea in rural western Kenya. Am J Trop Med Hyg 68:671–677

    PubMed  Google Scholar 

  • Bush K, Jacoby GA (2010) Updated functional classification of β-lactamases. Antimicrob Agents Chemother 54:969–976

    CAS  PubMed  Google Scholar 

  • Bush K, Jacoby GA, Medeiros AA (1995) A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother 39:1211–1233

    CAS  PubMed  PubMed Central  Google Scholar 

  • Camacho AI, Irache JM, de Souza J, Sánchez-Gómez S, Gamazo C (2013) Nanoparticle-based vaccine for mucosal protection against Shigella flexneri in mice. Vaccine 31:3288–3294

    CAS  PubMed  Google Scholar 

  • Cantas L, Shah SQA, Cavaco LM et al (2013) A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota. Front Microbiol 4:96

    CAS  PubMed  PubMed Central  Google Scholar 

  • Carattoli A (2009) Resistance plasmid families in Enterobacteriaceae. Antimicrob Agents Chemother 53:2227–2238

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cattoir V, Poirel L, Rotimi V et al (2007) Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 60:394–397

    CAS  PubMed  Google Scholar 

  • Chang Z, Zhang J, Ran L et al (2016) The changing epidemiology of bacillary dysentery and characteristics of antimicrobial resistance of Shigella isolated in China from 2004–2014. BMC Infect Dis 16:685

    PubMed  PubMed Central  Google Scholar 

  • Chen Z, Fang H, Wang L et al (2015) IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China. Sci Rep 4:7212

    Google Scholar 

  • Chisti MJ, Faruque ASG, Khan WA, Das SK, Zabed MB, Salam MA (2010) Characteristics of children with Shigella encephalopathy. Pediatr Infect Dis J 29:444–447

    PubMed  Google Scholar 

  • Choe YJ, Choe SA, Cho SI (2017) Importation of travel-related infectious diseases is increasing in South Korea: an analysis of salmonellosis, shigellosis, malaria, and dengue surveillance data. Travel Med Infect Dis 19:22–27

    PubMed  Google Scholar 

  • Chompook P, Samosornsuk S, Von Seidlein L et al (2005) Estimating the burden of shigellosis in Thailand: 36-month population-based surveillance study. Bull World Health Organ 83:739–746

    PubMed  PubMed Central  Google Scholar 

  • Chouchani C, Marrakchi R, Henriques I, Correia A (2013) Occurrence of IMP-8, IMP-10, and IMP-13 metallo-β-lactamases located on class 1 integrons and other extended-spectrum β-lactamases in bacterial isolates from Tunisian rivers. Scand J Infect Dis 45:95–103

    CAS  PubMed  Google Scholar 

  • Cui X, Yang C, Wang J et al (2015) Antimicrobial resistance of Shigella flexneri serotype 1b isolates in China. PLoS One 10:e0129009

    PubMed  PubMed Central  Google Scholar 

  • Czekalski N, Berthold T, Caucci S et al (2012) Increased levels of multi-resistant bacteria and resistance genes after wastewater treatment and their dissemination into Lake Geneva, Switzerland. Front Microbiol 3:106

    PubMed  PubMed Central  Google Scholar 

  • Dalhoff A (2012) Global fluoroquinolone resistance epidemiology and implictions for clinical use. Interdiscip Perspect Infect Dis 2012:1–37

    Google Scholar 

  • Danel F, Hall LM, Gur D, Livermore DM (1998) OXA-16, a further extended-spectrum variant of OXA-10 beta-lactamase, from two Pseudomonas aeruginosa isolates. Antimicrob Agents Chemother 42:3117–3122

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dantas G, Sommer MO (2014) How to fight back against antibiotic resistance. Am Sci 102:42–51

    Google Scholar 

  • Datta N, Kontomichalou P (1965) Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae. Nature 208:239–241

    CAS  PubMed  Google Scholar 

  • Dorman CJ, Porter ME (1998) The Shigella virulence gene regulatory cascade: a paradigm of bacterial gene control mechanisms. Mol Microbiol 29:677–684

    CAS  PubMed  Google Scholar 

  • DuPont HL, Hornick RB (1973) Adverse effect of lomotil therapy in shigellosis. JAMA 226:1525–1528

    CAS  PubMed  Google Scholar 

  • DuPont HL, Levine MM, Hornick RB, Formal SB (1989) Inoculum size in shigellosis and implications for expected mode of transmission. J Infect Dis 159:1126–1128

    CAS  PubMed  Google Scholar 

  • Dutta S, Rajendran K, Roy S, Chatterjee A, Dutta P, Nair GB, Bhattacharya SK, Yoshida SI (2002) Shifting serotypes, plasmid profile analysis and antimicrobial resistance pattern of Shigella strains isolated from Kolkata, India during 1995-2000. Epidemiol Infect 129:235–243

    CAS  PubMed  PubMed Central  Google Scholar 

  • Edwards BH (1999) Salmonella and Shigella species. Clin Lab Med 19:469–487

    CAS  PubMed  Google Scholar 

  • EFSA (European Food Safety Authority), ECDC (European Centre for Disease Prevention and Control) (2015) The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2014

  • Ekdahl K, Andersson Y (2005) The epidemiology of travel-associated shigellosis regional risks, seasonality and serogroups. J Inf Secur 51:222–229

    Google Scholar 

  • Eliopoulos GM, Huovinen P (2001) Resistance to trimethoprim-sulfamethoxazole. Clin Infect Dis 32:1608–1614

    Google Scholar 

  • Emmerson AM, Jones AM (2003) The quinolones: decades of development and use. J Antimicrob Chemother 51:13–20

    CAS  PubMed  Google Scholar 

  • Evans BA, Amyes SGB (2014) OXA-lactamases. Clin Microbiol Rev 27:241–263

    PubMed  PubMed Central  Google Scholar 

  • Farag TH, Faruque AS, Wu Y et al (2013) Housefly population density correlates with shigellosis among children in Mirzapur, Bangladesh: a time series analysis. PLoS Negl Trop Dis 7:e2280

    PubMed  PubMed Central  Google Scholar 

  • Farshad S, Sheikhi R, Japoni A, Basiri E, Alborzi A (2006) Characterization of strains in Iran by plasmid profile analysis and PCR amplification of ipa genes. J Clin Microbiol 44:2879–2883

    CAS  PubMed  PubMed Central  Google Scholar 

  • Faruque SM, Khan R, Kamruzzaman M, Yamasaki S, Ahmad QS, Azim T, Nair GB, Takeda Y, Sack DA (2002) Isolation of Shigella dysenteriae type 1 and S. flexneri strains from surface waters in Bangladesh: comparative molecular analysis of environmental Shigella isolates versus clinical strains. Appl Environ Microbiol 68:3908–3913

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fernandes R, Amador P, Oliveira C, Prudêncio C (2014) Molecular characterization of ESBL-producing Enterobacteriaceae in Northern Portugal. Sci World J 2014:782897

    Google Scholar 

  • Fernandez E, Escartin E, Ayala AC, Lozano JS (1989) Survival and growth of Salmonella and Shigella on sliced fresh fruit. J Food Prot 52:471–472

    Google Scholar 

  • Fulla N, Fulla F, Prado V et al (2005) Surveillance for antimicrobial resistance profiles among Shigella species isolated from a semirural community in the northern administrative area of Santiago, Chile. Am J Trop Med Hyg 72:851–854

    PubMed  Google Scholar 

  • Gebrekidan A, Dejene TA, Kahsay G, Wasihun AG (2015) Prevalence and antimicrobial susceptibility patterns of Shigella among acute diarrheal outpatients in Mekelle hospital, Northern Ethiopia. BMC Res Notes 8:611

    PubMed  PubMed Central  Google Scholar 

  • Gentle A, Ashton PM, Dallman TJ, Jenkins C (2016) Evaluation of molecular methods for serotyping Shigella flexneri. Bacteriology 54:1456–1461

    CAS  Google Scholar 

  • Getamesay M, Getenet B, Ahmed Z (2014) Prevalence of Shigella, Salmonella and Campylobacter species and their susceptibility patters among under five children with diarrhea in Hawassa Town, South Ethiopia. Ethiop J Health Sci 24:101

    Google Scholar 

  • Ghaemi EO, Aslani MM, Moradi AV, Dadgar T, Livani S, Mansourian AR, Nosrat SB, Ahmadi AR (2007) Epidemiology of Shigella-associated diarrhea in Gorgan, North of Iran. Saudi J Gastroenterol 13:129–132

    PubMed  Google Scholar 

  • Ghosh S, Pazhani GP, Niyogi SK, Nataro JP, Ramamurthy T (2014) Genetic characterization of Shigella spp. isolated from diarrhoeal and asymptomatic children. J Med Microbiol 63:903–910

    CAS  PubMed  Google Scholar 

  • Gillings MR, Stokes HW (2012) Are humans increasing bacterial evolvability? Trends Ecol Evol 27:346–352

    PubMed  Google Scholar 

  • Gupta A, Polyak CS, Bishop RD, Sobel J, Mintz ED (2004) Laboratory-confirmed shigellosis in the United States, 1989-2002: epidemiologic trends and an patterns. Clin Infect Dis 38:1372–1377

    PubMed  Google Scholar 

  • Gupta AK, Nayduch D, Verma P et al (2012) Phylogenetic characterization of bacteria in the gut of house flies (Musca domestica). FEMS Microbiol Ecol 79:581–593

    CAS  PubMed  Google Scholar 

  • Hammond DS, Harris T, Bell J, Turnidge J, Giffard PM (2008) Selection of SHV extended-spectrum-beta-lactamase-dependent cefotaxime and ceftazidime resistance in Klebsiella pneumoniae requires a plasmid-borne blaSHV gene. Antimicrob Agents Chemother 52:441–445

    CAS  PubMed  Google Scholar 

  • Hata M, Suzuki M, Matsumoto M, Takahashi M, Sato K, Ibe S, Sakae K (2005) Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob Agents Chemother 49:801–803

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hosangadi D, Smith PG, Kaslow DC, Giersing BK (2017) WHO consultation on ETEC and Shigella burden of disease, Geneva. Vaccine 6–7

  • Huang IF, Chiu CH, Wang MH, Wu CY, Hsieh KS, Chiou CC (2005) Outbreak of dysentery associated with ceftriaxone-resistant Shigella sonnei: first report of plasmid-mediated CMY-2-type AmpC-lactamase resistance in S. sonnei. J Clin Microbiol 43:2608–2612

    CAS  PubMed  PubMed Central  Google Scholar 

  • Islam D, Tzipori S, Islam M, Lindberg AA (1993) Rapid detection of Shigella dysenteriae and Shigella flexneri in faeces by an immunomagnetic assay with monoclonal antibodies. Eur J Clin Microbiol Infect Dis 12:25–32

    CAS  PubMed  Google Scholar 

  • Jacoby GA, Strahilevitz J, Hooper DC (2014) Plasmid-mediated quinolone resistance. Microbiol Spectr 2:1–42

    CAS  Google Scholar 

  • Jafari F, Hamidian M, Rezadehbashi M et al (2009) Prevalence and antimicrobial resistance of diarrheagenic Escherichia coli and Shigella species associated with acute diarrhea in Tehran, Iran. Can J Infect Dis Med Microbiol 20:e56–e62

    PubMed  PubMed Central  Google Scholar 

  • Jennison AV, Verma NK (2004) Shigella flexneri infection: pathogenesis and vaccine development. FEMS Microbiol Rev 28:43–58

    CAS  PubMed  Google Scholar 

  • Kendall ME, Crim S, Fullerton K et al (2012) Travel-associated enteric infections diagnosed after return to the United States, foodborne diseases active surveillance network (FoodNet), 2004-2009. Clin Infect Dis 54:s480–s487

    PubMed  Google Scholar 

  • Khalil K, Khan SR, Mazhar K et al (1998) Occurrence and susceptibility to antibiotics of Shigella species in stools of hospitalized children with bloody diarrhea in Pakistan. Am J Trop Med Hyg 58:200–803

    Google Scholar 

  • Khan E, Jabeen K, Ejaz M et al (2009) Trends in antimicrobial resistance in Shigella species in Karachi, Pakistan. J Infect Dev Ctries 10:798–802

    Google Scholar 

  • Khan S, Singh P, Asthana A, Ansari M (2013) Magnitude of drug resistant shigellosis in Nepalese patients. Iran J Microbiol 5:334–338

    PubMed  PubMed Central  Google Scholar 

  • Kim S, Kim J, Kang Y, Park Y, Lee B (2004) Occurrence of extended-spectrum β-lactamases in members of the genus Shigella in the Republic of Korea. J Clin Microbiol 42:5264–5269

    CAS  PubMed  PubMed Central  Google Scholar 

  • King CK, Glass R, Bresee JS (2003) Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep 52:1–16

    PubMed  Google Scholar 

  • Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM (1999) Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ 77:651–666

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kotloff KL, Platts-mills JA, Nasrin D et al (2017) Global burden of diarrheal diseases among children in developing countries: Incidence, etiology, and insights from new molecular diagnostic techniques. Vaccine 35:6783–6789

    PubMed  Google Scholar 

  • Kotloff KL, Riddle MS, Platts-mills JA et al (2018) Shigellosis. Lancet 391:801–812

    PubMed  Google Scholar 

  • Kumar A, Oberoi A, Alexander VS (2014) Prevalence and antimicrobial susceptibility patterns of Shigella in stool samples in a tertiary healthcare hospital of Punjab. J Heal Res 1:33–35

    CAS  Google Scholar 

  • Kuo C, Su L, Perera J et al (2008) Antimicrobial susceptibility of Shigella isolates in eight Asian countries, 2001-2004. J Microbiol Immunol Infect 41:107–111

    PubMed  Google Scholar 

  • Lee S, Park Y-J, Kim M et al (2005) Prevalence of Ambler class A and D beta-lactamases among clinical isolates of Pseudomonas aeruginosa in Korea. J Antimicrob Chemother 56:122–127

    CAS  PubMed  Google Scholar 

  • Leverstein-van Hall MA, Dierikx CM, Stuart JC et al (2011) Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains. Clin Microbiol Infect 17:873–880

    CAS  PubMed  Google Scholar 

  • Levine MM, Kotloff KL, Barry EM, Pasetti MF, Sztein MB (2007) Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road. Nat Rev Microbiol 5:540–553

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li ST, Grossman DC, Cummings P (2007) Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS Med 4:e98

    PubMed  PubMed Central  Google Scholar 

  • Li J, Li B, Ni YSJ (2015) Molecular characterization of the extended spectrum beta-lactamase (ESBL) producing Shigella spp. in Shanghai. Eur J Clin Microbiol Infect Dis 34:447–451

    CAS  PubMed  Google Scholar 

  • Lima IFN, Havt A, Lima AAM (2015) Update on molecular epidemiology of Shigella infection. Curr Opin Gastroenterol 31:30–37

    PubMed  Google Scholar 

  • Linder JA, Huang ES, Steinman MA, Gonzales R, Stafford RS (2005) Fluoroquinolone prescribing in the United States: 1995 to 2002. Am J Med 118:259–268

    PubMed  Google Scholar 

  • Liu G, Ling BD, Zeng Y, Lin L (2008) Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Enterobacter cloacae from a teaching hospital in China. Jpn J Infect Dis 61:286–289

    CAS  PubMed  Google Scholar 

  • Liu G, Qian H, Tang B, Chen Y, Kang H, Jiang F, Ma P, Gu B, Huo X (2018) Prevalence and characterisation of third-generation cephalosporin-resistant Shigella flexneri isolates from Jiangsu Province, China, 2013–2015. J Glob Antimicrob Resist 15:283–287

    PubMed  Google Scholar 

  • Livermore DM (1995) Beta-lactamases in laboratory and clinical resistance. Clin Microbiol Rev 8:557–584

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lluque A, Mosquito S, Gomes C, Riveros M, Durand D, Tilley DH, Bernal M, Prada A, Ochoa TJ, Ruiz J (2015) Virulence factors and mechanisms of antimicrobial resistance in Shigella strains from periurban areas of Lima (Peru). Int J Med Microbiol 305:480–490

    CAS  PubMed  PubMed Central  Google Scholar 

  • Louise K, Watkins FG (2019) Travel-related infectious diseases. In: Brunette GW, Nemhauser JB (eds) CDC Yellow Book 2020, CDC Health. Oxford University Press, pp 340–344

  • Mache A (2001) Antibiotic resistance and sero-groups of Shigella among paediatric out-patients in Southwest Ethiopia. East Afr Med J 78:296–299

    CAS  PubMed  Google Scholar 

  • Madhavan A, Balakrishnan SJV (2018) Antibiotic susceptibility pattern of Shigella isolates in a tertiary healthcare center. J Lab Physicians 10:140–144

    CAS  PubMed  PubMed Central  Google Scholar 

  • Majalan PA, Hajizade A, Nazarian S et al (2018) Investigating the prevalence of Shigella species and their antibiotic resistance pattern in children with acute diarrhea referred to selected hospitals in Tehran, Iran. J Appl Biotechnol Rep 5:70–74

    CAS  Google Scholar 

  • Martínez-Martínez L, Pascual A, Jacoby GA (1998) Quinolone resistance from a transferable plasmid. Lancet 351:797–799

    PubMed  Google Scholar 

  • Mashouf RY, Moshtaghi AA, Hashemi SH (2006) Epidemiology of Shigella species isolated from diarrheal children and drawing their antibiotic resistance pattern. Arch Clin Infect Dis 1:149–155

    Google Scholar 

  • Mengistu G, Lema T, Aseffa A (2014) Prevalence and antimicrobial susceptibility patterns of Salmonella serovars and Shigella species. Artic J Microb Biochem Technol S2:006

    Google Scholar 

  • Mitscher LA (2005) Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents. Chem Rev 105:559–592

    CAS  PubMed  Google Scholar 

  • Moezardalan K, Zali MR, Soltan MM (2003) Prevalence and pattern of antimicrobial resistance of Shigella species among patients with acute diarrhea in Karaj, Tehran, Iran. J Health Popul Nutr 21:96–102

    PubMed  Google Scholar 

  • Munshi MH, Sack DA, Haider K, Ahmed ZU, Rahaman MM, Morshed MG (1987) Plasmid-mediated resistance to Nalidixic acid in Shigella dysenteriae type 1. Lancet 2:419–421

    CAS  PubMed  Google Scholar 

  • Murphy GS, Bodhidatta L, Echeverria P, Tansuphaswadikul S, Hoge CW, Imlarp S, Tamura K (1993) Ciprofloxacin and Loperamide in the treatment of bacillary dysentery. Ann Intern Med 118:582–586

    CAS  PubMed  Google Scholar 

  • Naas T, Philippon L, Poirel L, Ronco E, Nordmann P (1999) An SHV-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa. Antimicrob Agents Chemother 43:1281–1284

    CAS  PubMed  PubMed Central  Google Scholar 

  • Naik DG (2006) Prevalence and antimicrobial susceptibility patterns of Shigella species in Asmara, Eritrea, Northeast Africa. J Microbiol Immunol Infect 39:392–395

    CAS  PubMed  Google Scholar 

  • Nataro JP, Seriwatana J, Fasano A et al (1995) Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains. Infect Immun 63:4721–4728

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ngoshe I, Denue B, Bello H et al (2017) Prevalence and antimicrobial susceptibility of Shigella species isolates from diarrheal stool of patients in a tertiary health facility in Northeastern Nigeria. Sub-Saharan Afr J Med 4:96

    Google Scholar 

  • Nguyen TV, Le Van P, Le Huy C et al (2006) Etiology and epidemiology of diarrhea in children in Hanoi, Vietnam. Int J Infect Dis 10:298–308

    Google Scholar 

  • Niyogi SK (2005) Shigellosis. J Microbiol 43:133–143

    PubMed  Google Scholar 

  • Nodeh Farahani N, Masjedian Jazi F, Nikmanesh B et al (2018) Prevalence and antibiotic susceptibility patterns of Salmonella and Shigella species isolated from pediatric diarrhea in Tehran. Arch Pediatr Infect Dis 6:e57328

    Google Scholar 

  • Nordmann P, Poirel L (2005) Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J Antimicrob Chemother 56:463–469

    CAS  PubMed  Google Scholar 

  • Noriega FR, Liao FM, Maneval DR et al (1999) Strategy for cross-protection among Shigella flexneri serotypes. Infect Immun 67:782–788

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nuesch-inderbinen M, Heini N, Zurfluh K et al (2016) Antimicrobial drug resistance mechanisms, 2004–2014. Emerg Infect Dis 22:1083–1085

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nunes M, Magalhaes PP, Penna FJ et al (2011) Diarrhea associated with Shigella in children and antimicrobial susceptibility. J Pediatr 88:125–128

    Google Scholar 

  • Olivares J, Bernardini A, Garcia-Leon G et al (2013) The intrinsic resistome of bacterial pathogens. Front Microbiol 4:103

    PubMed  PubMed Central  Google Scholar 

  • Olukoya DK, Oni O (1990) Plasmid profile analysis and antimicrobial susceptibility patterns of Shigella isolates from Nigeria. Epidemiol Infect 105:59–64

    CAS  PubMed  PubMed Central  Google Scholar 

  • Opintan JA, Newman MJ (2007) Distribution of serogroups and serotypes of multiple drug resistant Shigella isolates. Ghana Med J 41:7–11

    Google Scholar 

  • Orrett FA (2008) Prevalence of Shigella serogroups and their antimicrobial resistance patterns in Southern Trinidad. J Health Popul Nutr 26:456–462

    PubMed  PubMed Central  Google Scholar 

  • Panigrahi D, Agarwal KC, Verma AD, Dubey ML (1987) Incidence of shigellosis and multidrug resistant Shigellae: a 10 year study. J Trop Med Hyg 90:25–29

    CAS  PubMed  Google Scholar 

  • Parajuli P, Deimel LPVN (2019) Genome analysis of Shigella flexneri serotype 3b strain SFL1520 reveals significant horizontal gene acquisitions including a multidrug resistance cassette. Genome Biol Evol 11:776–785

    PubMed  PubMed Central  Google Scholar 

  • Park CH, Robicsek A, Jacoby GA, Sahm D, Hooper DC (2006) Prevalence in the United States of aac(6′)-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob Agents Chemother 50:3953–3955

    CAS  PubMed  PubMed Central  Google Scholar 

  • Paterson DL, Bonomo RA (2005) Extended-spectrum-lactamases: a clinical update. Clin Microbiol Rev 18:657–686

    CAS  PubMed  PubMed Central  Google Scholar 

  • Patwari A (1994) Multidrug resistant Shigella infections in children. J Diarrhoeal Dis Res 12:182–186

    CAS  PubMed  Google Scholar 

  • Pazhani GP, Niyogi SK, Singh AK, Sen B, Taneja N, Kundu M, Yamasaki S, Ramamurthy T (2008) Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. J Med Microbiol 57:856–863

    CAS  PubMed  Google Scholar 

  • Phalipon A, Tanguy M, Grandjean C et al (2009) A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection. J Immunol 182:2241–2247

    CAS  PubMed  Google Scholar 

  • Philippon LN, Naas T, Bouthors AT, Barakett V, Nordmann P (1997) OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa. Antimicrob Agents Chemother 41:2188–2195

    CAS  PubMed  PubMed Central  Google Scholar 

  • Poirel L, Girlich D, Naas T, Nordmann P (2001) OXA-28, an extended-spectrum variant of OXA-10-lactamase from Pseudomonas aeruginosa and its plasmid and integron located gene. Antimicrob Agents Chemother 45:447–453

    CAS  PubMed  PubMed Central  Google Scholar 

  • Poirel L, Cattoir V, Nordmann P (2012) Plasmid-mediated quinolone resistance; interactions between human, animal, and environmental ecologies. Front Microbiol 3:24

    PubMed  PubMed Central  Google Scholar 

  • Pourakbari B, Mamishi S, Mashoori N et al (2010) Frequency and antimicrobial susceptibility of Shigella species isolated in children medical center hospital, Tehran, Iran, 2001-2006. Braz J Infect Dis 14:153–157

    PubMed  Google Scholar 

  • Pu XY, Pan JC, Wang HQ, Zhang W, Huang ZC, Gu YM (2009) Characterization of fluoroquinolone resistant Shigella flexneri in Hangzhou area of China. J Antimicrob Chemother 63:917–920

    CAS  PubMed  Google Scholar 

  • Pu XY, Gu Y, Li J et al (2018) Characterization of the complete sequences and stability of plasmids carrying the genes aac(6′)-Ib-cr or qnrS in Shigella flexneri in the Hangzhou area of China. World J Microbiol Biotechnol 34:1–13

    CAS  Google Scholar 

  • Puzari M, Sharma M, Chetia P (2017) Emergence of antibiotic resistant Shigella species: a matter of concern. J Infect Public Health 11:451–454

    PubMed  Google Scholar 

  • Rafii F, Lunsford P (1997) Survival and detection of Shigella flexneri in vegetables and commercially prepared salads. J AOAC Int 80:1191–1197

    CAS  PubMed  Google Scholar 

  • Rahman S, Ali T, Ali I, Khan NA (2018) The growing genetic and functional diversity of extended- spectrum beta-lactamases. Biomed Res Int 2018:1–14

    Google Scholar 

  • Ranjbar R, Farahani A (2019) Shigella: antibiotic-resistance mechanisms and new horizons for treatment. Infect Drug Resist 12:3137–3167

    PubMed  PubMed Central  Google Scholar 

  • Ranjbar R, Soltan-Dallal MM, Pourshafie MR, Mammina C (2009) Antibiotic resistance among Shigella serogroups isolated in Tehran, Iran (2002-2004). J Infect Dev Ctries 3:647–648

    PubMed  Google Scholar 

  • Ranjbar R, Hosseini MJ, Kaffashian AR (2010) An outbreak of shigellosis due to Shigella flexneri serotype 3a in a prison in Iran. Arch Iran Med 13:413–416

    PubMed  Google Scholar 

  • Reller ME, Nelson JM, Molbak K et al (2006) A large, multiple-restaurant outbreak of infection with Shigella flexneri serotype 2a traced to tomatoes. Clin Infect Dis 42:163–169

    PubMed  Google Scholar 

  • Riddle MS, DuPont HL, Connor BA (2016) ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. 111:602–622

  • Roberts MC (2002) Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim, and sulfonamide drug classes. Mol Biotechnol 20:261–284

    CAS  PubMed  Google Scholar 

  • Robicsek A, Jacoby GA, Hooper DC (2006a) The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis 6:629–640

    CAS  PubMed  Google Scholar 

  • Robicsek A, Strahilevitz J, Jacoby GA et al (2006b) Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med 12:83–88

    CAS  PubMed  Google Scholar 

  • Sack DA, Lyke C, McLaughlin C, Suwanvanichkij V (2001) Antimicrobial resistance in Shigellosis, Cholera and Campylobacteriosis: WHO department of communicable disease surveillance and response 2001:21–30

  • Saeed A, Abd H, Edvinsson B, Sandström G (2009) Acanthamoeba castellanii an environmental host for Shigella dysenteriae and Shigella sonnei. Arch Microbiol 191:83–88

    CAS  PubMed  Google Scholar 

  • Saha T, Murhekar M, Hutin YJ (2009) An urban, water-borne outbreak of diarrhoea and shigellosis in a district town in eastern India. Natl Med J India 22:237–239

    CAS  PubMed  Google Scholar 

  • Saima, Samad A, Abbas F et al (2018) Isolation and identification of Shigella species from food and water samples of Quetta, Pakistan. Pure Appl Biol 7:227–235

    CAS  Google Scholar 

  • Sakhaei A, Savari M, Shokoohizadeh L et al (2015) Characterization of Shigella strains by plasmid profile analysis and antibiotic susceptibility patterns in a pediatric hospital in Ahvaz. Int J Enteric Pathog 3:29924

    Google Scholar 

  • Sambe-Ba B, Seck A, Wane AA et al (2013) Sensitivity to antibiotics and genetic support to resistance of Shigella flexneri strains isolated in Dakar from 2001 to 2010. Bull Soc Pathol Exot 106:89–94

    CAS  PubMed  Google Scholar 

  • Schroeder GN, Hilbi H (2008) Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion. Clin Microbiol Rev 21:134–156

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sethuvel DPM, Ragupathi NKD, Anandan S, Veeraraghavan B (2016) Update on: Shigella new serogroups/serotypes and their antimicrobial resistance. Lett Appl Microbiol 64:8–18

    Google Scholar 

  • Shah N, DuPont HL (2009) Global etiology of travelers’ diarrhea: systematic review from 1973 to the present. Am J Trop Med Hyg 80:609–614

    PubMed  Google Scholar 

  • Sharma A, Kumar S, Divya S (2009) Phenotypic and genotypic characterization of Shigella spp. with reference to its virulence genes and antibiogram analysis from river Narmada. Indian J Microbiol 49:259–265

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sheikh AF, Moosavian M, Abdi M, Heidary M, Shahi F, Jomehzadeh N, Seyed-Mohammadi S, Saki M, Khoshnood S (2019) Prevalence and antimicrobial resistance of Shigella species isolated from diarrheal patients in Ahvaz, southwest Iran. Infect Drug Resist 12:249–253

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shen H, Chen J, Xu Y, Lai Z, Zhang J, Yang H, Li Y, Jiang M, Ye Y, Bai X (2017) An outbreak of shigellosis in a Children Welfare Institute caused by a multiple antibiotic resistant strain of Shigella flexneri 2a. J Infect Public Health 10:814–818

    PubMed  Google Scholar 

  • Sherchand JB, Yokoo M, Sherchand O et al (2009) Burden of enteropathogens associated diarrheal diseases in children hospital, Nepal. Sci World 7:71–75

    Google Scholar 

  • Shiferaw SS, Palmer A, Joyce K, Barzilay EJ, Krueger ACP (2012) Antimicrobial susceptibility patterns of Shigella isolates in foodborne diseases active surveillance network (FoodNet) sites, 2000-2010. Clin Infect Dis 54:S458–S463

    CAS  PubMed  Google Scholar 

  • Siu LK, Lo JY, Yuen KY et al (2000) Beta-lactamases in Shigella flexneri isolates from Hong Kong and Shanghai and a novel OXA-1-like beta-lactamase, OXA-30. Antimicrob Agents Chemother 44:2034–2038

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stagg RM, Tang S, Carlin NIA, Talukder KA, Cam PD, Verma NK (2009) A novel glucosyltransferase involved in O-antigen modification of Shigella flexneri serotype 1c. J Bacteriol 191:6612–6617

    CAS  PubMed  PubMed Central  Google Scholar 

  • Steffen R (2005) Epidemiology traveler’s diarrhea. Clin Infect Dis 41:12–14

    Google Scholar 

  • Stephen Berger M (2019a) Shigellosis: global status: 2019 edition. Gideon Informatics, Inc, Los Angeles

    Google Scholar 

  • Stephen Berger MD (2019b) Infectious diseases of Mexico: 2019 edition. Gideon Informatics, Inc, Los Angeles

    Google Scholar 

  • Sun Q, Lan R, Wang Y, Zhao A, Zhang S, Wang J, Wang Y, Xia S, Jin D, Cui Z, Zhao H, Li Z, Ye C, Zhang S, Jing H, Xu J (2011) Development of a multiplex PCR assay targeting O-antigen modification genes for molecular serotyping of Shigella flexneri. J Clin Microbiol 49:3766–3770

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sun Q, Lan R, Wang Y et al (2013) Isolation and genomic characterization of SfI, a serotype-converting bacteriophage of Shigella flexneri. BMC Microbiol 13:39

    CAS  PubMed  PubMed Central  Google Scholar 

  • Surawicz CM (2007) Shigella: a sexually transmitted infection in men who have sex with men. Gastroenterology 133:1737–1738

    PubMed  Google Scholar 

  • Sutcliffe JG (1978) Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci 75:3737–3741

    CAS  PubMed  Google Scholar 

  • Talebreza A, Memariani M, Memariani H et al (2015) Prevalence and antibiotic susceptibility of Shigella species isolated from pediatric patients in Tehran. Arch Pediatr Infect Dis 4:e32395

    Google Scholar 

  • Talukder KA, Azmi IJ (2012) Population genetics and molecular epidemiology of Shigella species. In: Faruque SM (ed) Foodborne and waterborne bacterial pathogens epidemiology, evolution and molecular biology. Caister Academic Press, Norfolk

    Google Scholar 

  • Talukder KA, Islam Z, Islam MA, Dutta DK, Safa A, Ansaruzzaman M, Faruque AS, Shahed SN, Nair GB, Sack DA (2003) Phenotypic and genotypic characterization of provisional serotype Shigella flexneri 1c and clonal relationships with 1a and 1b strains isolated in Bangladesh. J Clin Microbiol 41:110–117

    CAS  PubMed  PubMed Central  Google Scholar 

  • Taneja N, Mewara A (2016) Shigellosis: epidemiology in India. Indian J Med Res 143:565–576

    PubMed  PubMed Central  Google Scholar 

  • Taneja N, Mewara A, Kumar A, Verma G, Sharma M (2012) Cephalosporin-resistant Shigella flexneri over 9 years (2001–09) in India. J Antimicrob Chemother 67:1347–1353

    CAS  PubMed  Google Scholar 

  • Tariq A, Haque A, Ali A, Bashir S, Habeeb MA, Salman M (2012) Molecular profiling of antimicrobial resistance and integron association of multidrug-resistant clinical isolates of Shigella species from Faisalabad, Pakistan. Can J Microbiol 58:1047–1054

    CAS  PubMed  Google Scholar 

  • Tenover FC, Raney PM, Williams PP, Rasheed JK, Biddle JW, Oliver A, Fridkin SK, Jevitt L, McGowan JE Jr, Project ICARE (2003) Evaluation of the NCCLS extended-spectrum beta-lactamase confirmation methods for Escherichia coli with isolates collected during Project ICARE. J Clin Microbiol 41:3142–3146

    CAS  PubMed  PubMed Central  Google Scholar 

  • Thomas CM, Nielsen KM (2005) Mechanisms of and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol 3:711–721

    CAS  PubMed  Google Scholar 

  • Torres AG (2004) Current aspects of Shigella pathogenesis. Rev Latinoam Microbiol 46:89–97

    PubMed  Google Scholar 

  • Trepanier S, Bui YG, Blackburn M, Milord F, Levac E (2014) Travel-related shigellosis in Quebec, Canada: an analysis of risk factors. J Travel Med 21:304–309

    PubMed  Google Scholar 

  • Ud-Din AIMS, Wahid SUH, Latif HA et al (2013) Changing trends in the prevalence of Shigella species: emergence of multidrug resistant Shigella sonnei biotype g in Bangladesh. PLoS One 8:e82601

    PubMed  PubMed Central  Google Scholar 

  • Venkatesan MM, Goldberg MB, Rose DJ, Grotbeck EJ, Burland V, Blattner FR (2001) Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri. Infect Immun 69:3271–3285

    CAS  PubMed  PubMed Central  Google Scholar 

  • Vicens R, Richard C, Coulanges P, Rasoamamunjy MA (1987) A reservoir of Shigella of avian origin: herons and birds of prey of the zoological garden in Tananarive. Bull Soc Pathol Exot Filiales 80:295–300

    CAS  PubMed  Google Scholar 

  • Victora CG, Bryce J, Fontaine O, Monasch R (2000) Reducing deaths from diarrhoea through oral rehydration therapy. Bull World Health Organ 78:1246–1255

    CAS  PubMed  PubMed Central  Google Scholar 

  • Von Seidlein L, Kim DR, Ali M et al (2006) A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology. PLoS Med 3:e353

    Google Scholar 

  • Walther-Rasmussen J, Hoiby N (2006) OXA-type carbapenemases. J Antimicrob Chemother 57:373–383

    CAS  PubMed  Google Scholar 

  • Wang XY, Du L, Von Seidlein L et al (2005) Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study. Am J Trop Med Hyg 73:416–422

    PubMed  Google Scholar 

  • Warren BR, Parish ME, Schneider KR (2006) Shigella as a foodborne pathogen and current methods for detection in food. Crit Rev Food Sci Nutr 46:551–567

    CAS  PubMed  Google Scholar 

  • Webb EC (1984) Enzyme nomenclature 1984. Wiley (10.1111)

  • Werner NL, Hecker MT, Sethi AK, Donskey CJ (2011) Unnecessary use of fluoroquinolone antibiotics in hospitalized patients. BMC Infect Dis 11:187

    CAS  PubMed  PubMed Central  Google Scholar 

  • WHO (2017) The selection and use of essential medicines: WHO technical report series 1006:1–604

  • Wiegand I, Geiss HK, Mack D, Stürenburg E, Seifert H (2007) Detection of extended-spectrum beta-lactamases among Enterobacteriaceae by use of semiautomated microbiology systems and manual detection procedures. J Clin Microbiol 45:1167–1174

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wilson G, Easow JM, Mukhopadhyay C, Shivananda PG (2006) Isolation and antimicrobial susceptibility of Shigella from patients with acute gastroenteritis in western Nepal. Indian J Med Res 123:145–150

    CAS  PubMed  Google Scholar 

  • Winokur PL, Canton R, Casellas J, Legakis N (2001) Variations in the prevalence of strains expressing an extended-spectrum β-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region. Clin Infect Dis 32:S94–S103

    CAS  PubMed  Google Scholar 

  • Xia S, Xu B, Huang L, Zhao JY, Ran L, Zhang J, Chen H, Pulsrikarn C, Pornruangwong S, Aarestrup FM, Hendriksen RS (2011) Prevalence and characterization of human Shigella infections in Henan Province, China, in 2006. J Clin Microbiol 49:232–242

    PubMed  Google Scholar 

  • Yang C, Li P, Zhang X et al (2016) Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China. Sci Rep 6:29124

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yates J (2005) Traveler’s diarrhea. Am Fam Physician 71:2095–2100

    PubMed  Google Scholar 

  • Ye C, Lan R, Xia S, Zhang J, Sun Q, Zhang S, Jing H, Wang L, Li Z, Zhou Z, Zhao A, Cui Z, Cao J, Jin D, Huang L, Wang Y, Luo X, Bai X, Wang Y, Wang P, Xu Q, Xu J (2010) Emergence of a new multidrug-resistant serotype x variant in an epidemic clone of Shigella flexneri. J Clin Microbiol 48:419–426

    CAS  PubMed  Google Scholar 

  • Yohannes G, Drasar A (1991) Molecular epidemiology of plasmid patterns in Shigella flexneri types 1-6. Epidemiol Infect 107:321–334

    Google Scholar 

  • Zafar A, Hasan R, Nizami SQ, von Seidlein L, Soofi S, Ahsan T, Chandio S, Habib A, Bhutto N, Siddiqui FJ, Rizvi A, Clemens JD, Bhutta ZA (2009) Frequency of isolation of various subtypes and antimicrobial resistance of Shigella from urban slums of Karachi, Pakistan. Int J Infect Dis 13:668–672

    PubMed  Google Scholar 

  • Zafer MM, Al-Agamy MH, El-Mahallawy HA et al (2014) Antimicrobial resistance pattern and their Beta-lactamase encoding genes among Pseudomonas aeruginosa strains isolated from cancer patients. Biomed Res Int 2014:101635

    PubMed  PubMed Central  Google Scholar 

  • Zamanlou S, Rezaee AM, Aghazadeh MGR, Babaie FKY (2018) Characterization of integrons, extended-spectrum beta-lactamases, AmpC cephalosporinase, quinolone resistance, and molecular typing of Shigella spp. from Iran. Infect Dis (Lond) 50:616–624

    CAS  Google Scholar 

  • Zhang CL, Liu QZ, Wang J et al (2014) Epidemic and virulence characteristic of Shigella spp. with extended-spectrum cephalosporin resistance in Xiaoshan District, Hangzhou, China. BMC Infect Dis 14:260

    PubMed  PubMed Central  Google Scholar 

  • Zhu Z, Cao M, Zhou X et al (2017) Epidemic characterization and molecular genotyping of Shigella flexneri isolated from calves with diarrhea in Northwest China. Antimicrob Resist Infect Control 6:1–11

    Google Scholar 

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  1. Department of Microbiology, Kohat University of Science and Technology, Kohat, Pakistan

    Iqbal Nisa, Muhammad Qasim & Nusrat Yasin

  2. Bacteriology Laboratory Center of Microbiology and Bacteriology (CMB) Veterinary Research Institute, Peshawar, Pakistan

    Rafi Ullah & Anwar Ali

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Nisa, I., Qasim, M., Yasin, N. et al. Shigella flexneri: an emerging pathogen. Folia Microbiol 65, 275–291 (2020). https://doi.org/10.1007/s12223-020-00773-w

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