Skip to main content
SpringerLink
Log in

Neonatal calf meningitis associated with Streptococcus gallolyticus subsp. gallolyticus

  • Original Article
  • Published:
Folia Microbiologica Aims and scope Submit manuscript

Abstract

Here, we report a case of neonatal calf meningitis due to Streptococcus gallolyticus subsp. gallolyticus (SGG). Clinical, pathological and microbiological findings were evaluated. API Strep, 16S rRNA gene sequencing, rpoB gene sequencing and sodA gene sequencing were used for the complete identification of SGG. This is the first documented report of neonatal calf meningitis due to SGG in veterinary medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Al-Sagair OA, Fathalla SI, Abdel-Rahman HA (2005) Reference values and age-related changes in cerebrospinal fluid and blood components in the clinically normal male dromedary camel. J Anim Vet Adv 4:470–472

    Google Scholar 

  • Aydin F, Gümüşsoy KS, Atabay HI, Iça T, Abay S (2007) Prevalence and distribution of Arcobacter species in various sources in Turkey and molecular analysis of isolated strains by ERIC-PCR. J Appl Microbiol 103:27–35

    Article  CAS  PubMed  Google Scholar 

  • Bauer AW, Kirby WMM, Sherris JC, Turek M (1966) Antibiotic susceptibility testing by a standardized single disc method. Am J Clin Pathol 45:493–496

    Article  CAS  PubMed  Google Scholar 

  • Beck M, Frodl R, Funke G (2008) Comprehensive study of strains previously designated Streptococcus bovis consecutively isolated from human blood cultures and emended description of Streptococcus gallolyticus and Streptococcus infantarius subsp. coli. J Clin Microbiol 46:2966–2972

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beneteau A, Levy C, Foucaud P, Béchet S, Cohen R, Raymond J, Dommergues MA (2015) Childhood meningitis caused by Streptococcus bovis group: clinical and biologic data during a 12-year period in France. Pediatr Infect Dis J 34:136–139

    Article  PubMed  Google Scholar 

  • Boleij A, Tjalsma H (2013) The itinerary of Streptococcus gallolyticus infection in patients with colonic malignant disease. Lancet Infect Dis 13:719–724

    Article  PubMed  Google Scholar 

  • Butt J, Romero-Hernández B, Pérez-Gómez B, Willhauck-Fleckenstein M, Holzinger D, Martin V, Moreno V, Linares C, Dierssen-Sotos T, Barricarte A, Tardón A, Altzibar JM, Moreno-Osset E, Franco F, Requena RO, Huerta JM, Michel A, Waterboer T, Castaño-Vinyals G, Kogevinas M, Pollán M, Boleij A, de Sanjosé S, Del Campo R, Tjalsma H, Aragonés N, Pawlita M (2016) Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: serological evidence. Int J Cancer 138:1670–1679

    Article  CAS  PubMed  Google Scholar 

  • Clinical and Laboratory Standards Institute (CLSI) (2008a) Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard-third edition M31-A3 Vol. 28 no. 8 replaces M31-A2 Vol. 22 no. 6. Wayne, Pennsylvania

  • Clinical and Laboratory Standards Institute (CLSI) (2008b) Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; approved guideline. CLSI document MM18-A (ISBN 1-56238-664-6). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087 USA

  • Corredoira J, Alonso MP, García-Garrote F, García-Pais MJ, Coira A, Rabuñal R, Gonzalez-Ramirez A, Pita J, Matesanz M, Velasco D, López-Álvarez MJ, Varela J (2014) Streptococcus bovis group and biliary tract infections: an analysis of 51 cases. Clin Microbiol Infect 20:405–409

    Article  CAS  PubMed  Google Scholar 

  • Corredoira-Sánchez J, García-Garrote F, Rabuñal R, López-Roses L, García-País MJ, Castro E, González-Soler R, Coira A, Pita J, López-Álvarez MJ, Alonso MP, Varela J (2012) Association between bacteremia due to Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis I) and colorectal neoplasia: a case-control study. Clin Infect Dis 55:491–496

    Article  PubMed  Google Scholar 

  • Dekker JP, Lau AF (2016) An update on the Streptococcus bovis Group: Classification, identification, and disease associations. J Clin Microbiol 54:1694–1699

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Drancourt M, Roux V, Fournier PE, Raoult D (2004) rpoB gene sequence-based identification of aerobic gram-positive cocci of the genera Streptococcus, Enterococcus, Gemella, Abiotrophia, and Granulicatella. J Clin Microbiol 42:497–504

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Droual R, Ghazikhanian GY, Shivaprasad HL, Barr BC, Bland MB (1997) Streptococcus bovis infection in turkey poults. Avian Pathol 26:433–439

    Article  CAS  PubMed  Google Scholar 

  • Dumke J, Hinse D, Vollmer T, Knabbe C, Dreier J (2014) Development and application of a multilocus sequence typing scheme for Streptococcus gallolyticus subsp. gallolyticus. J Clin Microbiol 52:2472–2478

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dumke J, Hinse D, Vollmer T, Schulz J, Knabbe C, Dreier J (2015) Potential transmission pathways of Streptococcus gallolyticus subsp. gallolyticus. PLoS One 15:e0126507

    Article  CAS  Google Scholar 

  • Dumke J, Vollmer T, Akkermann O, Knabbe C, Dreier J (2017) Case-control study: determination of potential risk factors for the colonization of healthy volunteers with Streptococcus gallolyticus subsp. gallolyticus. PLoS One 12:e0176515

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fecteau G, Smith BP, George LW (2009) Septicemia and meningitis in the newborn calf. Vet Clin North Am Food Anim Pract 25:195–208

    Article  PubMed  Google Scholar 

  • García-País MJ, Rabuñal R, Armesto V, López-Reboiro M, García-Garrote F, Coira A, Pita J, Rodríguez-Macías AI, López-Álvarez MJ, Alonso MP, Corredoira J (2016) Streptococcus bovis septic arthritis and osteomyelitis: a report of 21 cases and a literature review. Semin Arthritis Rheum 45:738–746

    Article  PubMed  Google Scholar 

  • Hogg R, Pearson A (2009) Streptococcus gallolyticus subspecies gallolyticus infection in ducklings. Vet Rec 5:297–298

    Article  Google Scholar 

  • Jans C, Meile L, Lacroix C, Stevens MJ (2015) Genomics, evolution, and molecular epidemiology of the Streptococcus bovis/Streptococcus equinus complex (SBSEC). Infect Genet Evol 33:419–436

    Article  CAS  PubMed  Google Scholar 

  • Kambarev S, Pecorari F, Corvec S (2017) Draft genome sequences of two highly erythromycin-resistant Streptococcus gallolyticus subsp. gallolyticus isolates containing a novel Tn916-like element, Tn6331. Genome Announc 20:e00226–e00217

    Google Scholar 

  • Kaneko J, Harvey J, Bruss M (2008) Clinical biochemistry of domestic animals, 6th edn. Academic Press, Burlington, MA, USA

    Google Scholar 

  • Klinkon M, Ježek J (2012) Values of blood variables in calves, a bird's-eye view of veterinary medicine, (Eds), Carlos, C., Perez-Marin ISBN, 978-953-51-0031-7, http://www.intechopen.com/books/a-bird-s-eye-view-of-veterinary-medicine/values-of-blood-variables-in-calves

  • Lane DJ (1991) 16S/23S rRNA sequencing. In: Stackebrandt E, Goodfellow M (eds) Nucleic acid techniques in bacterial systematics. John Wiley & Sons, New York, NY, USA, p 115e175

    Google Scholar 

  • Nazifi S, Rezakhani A, Badran M (1997) Evaluation of hematological, serum biochemical and cerebrospinal fluid parameters in experimental bacterial meningitis in the calf. Zentralbl Veterinarmed A 44:55–63

    Article  CAS  PubMed  Google Scholar 

  • Osawa R, Fujisawa T, Sly LI (1995) Streptococcus gallolyticus sp. nov.; gallate degrading organisms formerly assigned to Streptococcus bovis. Syst Appl Microbiol 18:74–78

    Article  Google Scholar 

  • Poyart C, Quesne G, Coulon S, Berche P, Trieu-Cuot P (1998) Identification of streptococci to species level by sequencing the gene encoding the manganese-dependent superoxide dismutase. J Clin Microbiol 36(1):41–47

    CAS  PubMed  PubMed Central  Google Scholar 

  • Poyart C, Quesne G, Trieu-Cuot P (2002) Taxonomic dissection of the Streptococcus bovis group by analysis of manganese-dependent superoxide dismutase gene (sodA) sequences: reclassification of ‘Streptococcus infantarius subsp. coli’ as Streptococcus lutetiensis sp. nov. and of Streptococcus bovis biotype II.2 as Streptococcus pasteurianus sp. nov. Int J Syst Evol Microbiol 52:1247–1255

    CAS  PubMed  Google Scholar 

  • Quinn PJ, Markey BK, Leonard FC, Fitzpatrick ES, Fanning S, Hartigan PJ (2011) Veterinary microbiology and microbial disease, 2nd.edn edn. Wiley-Blackwell, UK

    Google Scholar 

  • Russell KE, Roussel AJ (2007) Evaluation of the ruminant serum chemistry profile. Vet Clin North Am Food Anim Pract 23:403–426

    Article  PubMed  Google Scholar 

  • van Samkar A, Brouwer MC, Pannekoek Y, van der Ende A, van de Beek D (2015) Streptococcus gallolyticus meningitis in adults: report of five cases and review of the literature. Clin Microbiol Infect 21:1077–1083

    Article  PubMed  Google Scholar 

  • Sasaki E, Osawa R, Nishitani Y, Whiley RA (2004) ARDRA and RAPD analyses of human and animal isolates of Streptococcus gallolyticus. J Vet Med Sci 66:1467–1470

    Article  CAS  PubMed  Google Scholar 

  • Schlegel L, Grimont F, Ageron E, Grimont PA, Bouvet A (2003) Reappraisal of the taxonomy of the Streptococcus bovis/Streptococcus equinus complex and related species: description of Streptococcus gallolyticus subsp. gallolyticus subsp. nov., S. gallolyticus subsp. macedonicus subsp. nov. and S. gallolyticus subsp. pasteurianus subsp. nov. Int J Syst Evol Microbiol 53:631–645

    Article  CAS  PubMed  Google Scholar 

  • Schulz J, Dumke J, Hinse D, Dreier J, Habig C, Kemper N (2015) Organic turkey flocks: a reservoir of Streptococcus gallolyticus subspecies gallolyticus. PLoS One 10:e0144412

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Scott PR, Penny CD (1993) A field study of meningoencephalitis in calves with particular reference to analysis of cerebrospinal fluid. Vet Rec 133:119–121

    Article  CAS  PubMed  Google Scholar 

  • Seimiya Y, Ohshima K, Itoh H, Ogasawara N, Okutomo M, Tanaka S (1992) Clinicopathology of meningoventriculitis due to Streptococcus bovis infection in neonatal calves. J Vet Med Sci 54:871–874

    Article  CAS  PubMed  Google Scholar 

  • Sekizaki T, Nishiya H, Nakajima S, Nishizono M, Kawano M, Okura M, Takamatsu D, Nishino H, Ishiji T, Osawa R (2008) Endocarditis in chickens caused by subclinical infection of Streptococcus gallolyticus subsp. gallolyticus. Avian Dis 52:183–186

    Article  PubMed  Google Scholar 

  • Smith BP (2015) Manifestations and management of disease in neonatal ruminants. In: House JK, Smith GW, Mc Guirk SM, Gunn AA, Izzo M (eds) Large animal internal medicine, Fifth edition. Elseiver, New York, pp 303–306

    Google Scholar 

  • St Jean G, Yvorchuk-St Jean K, Anderson DE, Moore WE (1997) Cerebrospinal fluid constituents collected at the atlanto-occipital site of xylazine hydrochloride sedated, healthy 8-week-old Holstein calves. Can J Vet Res 61:108–112

    CAS  PubMed  PubMed Central  Google Scholar 

  • Turgut K, Başoğlu A, Sevinç M, Şen I, Yıldız M (1998) Plasma transfusion in calves with failure of passive colostral transfer. T J Vet Anim Sci 22:123–130

    Google Scholar 

  • Velarde R, Abarca ML, Lavin S, Marco I (2009) Haemorrhages in the pulmonary artery and aortic valve associated with Streptococcus gallolyticus subspecies gallolyticus in a roe deer. Vet Rec 22:237–239

    Google Scholar 

  • Vollmer T, Hinse D, Kleesiek K, Dreier J (2010) Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells. BMC Microbiol 10:78

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weaver DM, Tyler JW, VanMetre DC, Hostetler DE, Barrington GM (2000) Passive transport of colostral immunoglobulins in calves. J Vet Intern Med 14:569–577

    Article  CAS  PubMed  Google Scholar 

  • Welles EG, Tyler JW, Sorjonen DC, Whatley EM (1992) Composition and analysis of cerebrospinal fluid in clinically normal adult cattle. Am J Vet Res 53:2050–2057

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey

    Fuat Aydın, Seçil Abay, Emre Karakaya & Kadir Semih Gümüşsoy

  2. Department of Internal Medicine, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey

    Vehbi Güneş & Gencay Ekinci

  3. Department of Pathology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey

    Latife Çakır Bayram

  4. School of Burdur Vocational Education, Department of Veterinary Science, Mehmet Akif Ersoy University, Burdur, Turkey

    Kemal Varol

  5. Department of Microbiology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

    Hamit Kaan Müştak & Kadir Serdar Diker

Authors
  1. Fuat Aydın
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vehbi Güneş
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Latife Çakır Bayram
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seçil Abay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Emre Karakaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kemal Varol
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gencay Ekinci
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kadir Semih Gümüşsoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hamit Kaan Müştak
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kadir Serdar Diker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Seçil Abay.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aydın, F., Güneş, V., Çakır Bayram, L. et al. Neonatal calf meningitis associated with Streptococcus gallolyticus subsp. gallolyticus. Folia Microbiol 64, 223–229 (2019). https://doi.org/10.1007/s12223-018-0649-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12223-018-0649-5

Search

Navigation