Abstract
Invasive fungal diseases are severe complication of the lung transplant patients’ follow-up as they are increasing the risk of rejection. We report a patient who developed possible Tyromyces fissilis co-infection during graft rejection episode 2 years after bilateral lung transplantation for cystic fibrosis. The fungus was detected using conventional culture methods as a filamentous basidiomycete and further placed to T. fissilis species based on internal transcribed spacer (ITS) rDNA sequences. The patient was treated according to the susceptibility testing results by voriconazole in combination with the anti-rejection therapy and recovered completely within few weeks. This is, to our knowledge, the first published case report of T. fissilis as a possible causative agent of an infection/rejection episode in a lung transplant recipient.
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Acknowledgments
The authors wish to thank Dana Michalska for the technical laboratory support, Dr. Petra Dusatkova for her kind assistance with the sequence analysis, Dr. Zuzana Antusova for the clinical data collection and Dr. Hundie Tesfay and Mr. Eva Klapkova for the therapeutic drug levels interpretation. This study is supported by MH CZ-DRO, University Hospital Motol, Prague, Czech Republic 00064203.
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This study was performed in Motol University Hospital, Prague, Czech Republic.
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Chrenkova, V., Kolarik, M., Hubacek, P. et al. Possible Tyromyces fissilis (Basidiomycota, Polyporales) co-infection in a lung transplant recipient. Folia Microbiol 60, 33–35 (2015). https://doi.org/10.1007/s12223-014-0336-0
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DOI: https://doi.org/10.1007/s12223-014-0336-0