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Bone grafts as vancomycin carriers in local therapy of resistant infections

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Abstract

The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to what extent vancomycin (Van) bound to ground bone grafts is usable in the treatment of serious infections. The levels of released Van significantly exceeded the Van minimum inhibitory concentration, which can suppress Van-sensitive staphylococci and Van intermediate Staphylococcus aureus, for the whole period of a 16-day measurement. Our results indicate that bone grafts can be used as Van carriers in therapy of osteomyelitis caused by Van-sensitive Staphylococcus strains.

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Abbreviations

Van:

Vancomycin

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Acknowledgments

The financial support by the project MZCR for conceptual development of research organization 00064203 is gratefully acknowledged.

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Authors and Affiliations

  1. First Clinic of Orthopedics, Charles University, First Faculty of Medicine and Motol Faculty Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic

    P. Melicherčík, D. Jahoda, V. Barták, I. Landor, D. Pokorný, T. Judl & A. Sosna

  2. Institute of Medical Microbiology, Charles University, Second Faculty of Medicine and Motol Faculty Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic

    O. Nyč

  3. Institute of Clinical Biochemistry and Pathobiochemistry, Charles University, Second Faculty of Medicine and Motol Faculty Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic

    E. Klapková

Authors
  1. P. Melicherčík
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  2. D. Jahoda
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  3. O. Nyč
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  4. E. Klapková
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  5. V. Barták
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  6. I. Landor
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  7. D. Pokorný
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  8. T. Judl
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  9. A. Sosna
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Correspondence to D. Jahoda.

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Melicherčík, P., Jahoda, D., Nyč, O. et al. Bone grafts as vancomycin carriers in local therapy of resistant infections. Folia Microbiol 57, 459–462 (2012). https://doi.org/10.1007/s12223-011-0093-2

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  • DOI: https://doi.org/10.1007/s12223-011-0093-2

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