Folia Microbiologica

, Volume 55, Issue 1, pp 61–67

Efficacy of Rhodotorula glutinis and Spirulina platensis carotenoids in immunopotentiation of mice infected with Candida albicans SC5314 and Pseudomonas aeruginosa 35

  • M. M. El-Sheekh
  • Y. A. -G. Mahmoud
  • A. M. Abo-Shady
  • W. Hamza
Article

Abstract

Enhancement of the immune response leading to protection against bacterial and fungal infections was shown using different schedules of immunization with microbial pigments and a polysaccharide. The group of mice given carotenoids of Rhodotorula glutinis (preparation I) and polysaccharide of Spitulina platensis (IV) survived for 2 weeks after Pseudomonas aeruginosa infection. The groups of mice given carotenoids (I), polysaccharide (IV), I+IV and with the crude phycocyanin of S. platensis (III)+IV survived for 2 weeks after Candida albicans infection. All other groups recorded a maximum level of mortality reaching 2 mice per group either after immunization or post-infection. Adding the carotenoids, phycocyanin and polysaccharides to food as additives might therefore enhance the human immune response against microbial infections.

Abbreviations

BCG-CWS

cell wall component from Bacillus tuberculosis

CFU

colony forming unit

HWE

hot water extract

C.a.

Candida albicans

R.g.

Rhodotorula glutinis

IFN

interferon

IL

interleukin

PBS

phosphate-buffered saline

P.a.

Pseudomonas aeruginosa

S.p.

Spirulina platensis

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Copyright information

© Institute of Microbiology, v.v.i, Academy of Sciences of the Czech Republic 2010

Authors and Affiliations

  • M. M. El-Sheekh
    • 1
  • Y. A. -G. Mahmoud
    • 1
  • A. M. Abo-Shady
    • 1
  • W. Hamza
    • 1
  1. 1.Botany Department, Faculty of ScienceTanta UniversityTantaEgypt

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