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In Vitro susceptibility to selected antibiotics in bacteria of the Bacteroides fragilis group

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Abstract

Susceptibility of strains of Bacteroides fragilis group (1284 isolates from cancerous and noncancerous patients in 1994–2004) showed an increase in resistance toward some antibiotics (by 9 % toward penicillin and 8 % toward clindamycin) compared with the resistance level of 10 years ago. The increase in resistance was not detected in the case of ampicillin + sulbactam and metronidazole.

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Abbreviations

BAFR:

Bacteroides fragilis (group)

EUCAST:

European Committee on Antimicrobial Susceptibility Testing

MIC:

minimum inhibitory concentration

NCCLS:

National Committee for Clinical Laboratory Standards

AIN:

ampicillin + sulbactam

CLI:

clindamycin

MET:

metronidazole

PEN(s):

penicillin(s)

BADI:

Bacteroides distasonis

BAEG:

Bacteroides eggerthi

BAFR:

Bacteroides fragilis

BAOV:

Bacteroides ovatus

BATH:

Bacteroides thetaiotaomicron

BAVU:

Bacteroides vulgatus

References

  • Aldridge K.E., Ashcraft D., Cambre K., Pierson C.L., Jenkins S.G., Rosenblatt J.E.: Multicenter survey of the changing in vitro antimicrobial suceptibilities of clinical isolates of Bacteroides fragilis group, Prevotella, Fusobacterrium, Porphyromonas and Peptostreptococcus species. Antimicrob.Agents Chemother. 45, 1238–1243 (2001).

    Article  CAS  PubMed  Google Scholar 

  • Betriu C., Campos E., Cabronero C., Rodriguez-Avial C., Picazo J.J.: Susceptibility of species of the Bacteroides fragilis group to 10 antimicrobial agents. Antimicrob.Agents Chemother. 44, 671–673 (1990).

    Google Scholar 

  • Brazier J.S., Stubs S.T., Duerden B.I.: Metronidazole resistance among clinical isolates belonging to the Bacteroides fragilis group: time to be concerned? J.Antimicrob.Chemother. 44, 580–581 (1999).

    Article  CAS  PubMed  Google Scholar 

  • Breuil J., Dublanchet A., Truffaut N., Sebald M.: Transferable 5-nitroimidazole resistance in the Bacteroides fragilis group. Plasmid 21, 151–154 (1989).

    Article  CAS  PubMed  Google Scholar 

  • Eady E.A., Jones C.E., Tipper J.I., Cove J.H., Cunliffe W.J., Layton A.M.: Antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage. Brit.Med.J. 306, 555–556 (1993).

    Article  CAS  PubMed  Google Scholar 

  • Edwards D.I.: Resistance to nitroimidazoles in anaerobes, pp. 437–448 in Anaerobic Pathogens (A.R. Ely, K.W. Bennet, Eds). Academic Press, Shefield (UK) 1997.

    Google Scholar 

  • EUCAST (European Committee on Antimicrobial Susceptibility Testing): Antimicrobial wild type MIC distributions of microorganism; http://www.srga.org/eucastwt/WT_EUCAST.htm (2007).

  • Freeman C., Dklutman N.E., Lamp K.: Metronidazole — a therapeutic review and update. Drugs 54, 679–708 (1997).

    Article  CAS  PubMed  Google Scholar 

  • Haggoud A., Ait M’Hand R., Eysset G.E., M’Daghri N., Benbachir M., Moummi M.: Prevalence and characteristic of nim genes encoding 5-nitroimidazole resistance among Bacteroides fragilis strains isolated in Morocco. Microb.Drug Resist. 7, 177–181 (2001).

    Article  CAS  PubMed  Google Scholar 

  • Hecht D.W.: Resistance trends in anaerobic bacteria. Clin.Microbiol.Newslett. 22, 41–44 (2001).

    Article  Google Scholar 

  • Hedberg M., Nord C.E. and ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria (G. Feierl, M. Marina, S. Kalenic, D. Chmelař, A. Bremmelgaard, J. Brazier, H. Jousimies-Somer, L. Dubreuil, A. Lozniewski, F. Mory, M. Claros, E. Bezirtzoglou, Z. Lajos, E. Nagy, R. Todorova, K.G. Kristinsson, M. Grazia Menozzi, H. Endtz, F. Meisel-Mikolajczyk, J. Kolman, J. Vila, C. Jarstrand, R. Zbinden): Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe. Clin.Microbiol.Infect. 9, 475–488 (2003).

    Article  CAS  PubMed  Google Scholar 

  • Leyden J.J., Mcginley K.J., Cavalieri S., Webster C.F., Mells O.H., Kligman A.M.: Propionibacterium acnes resistance to antibiotics in acne patients. J.Am.Acad.Dermatol. 8, 41–45 (1993).

    Article  Google Scholar 

  • NCCLS (National Committee for Clinical Laboratory Standards): Methods for antimicrobial susceptibility testing of anaerobic bacteria, 6th ed. Approved Standard M-11-A6. Wayne (USA) 2004.

    Google Scholar 

  • O’Donoghue M.A., Potter J., Allen K.: Metronidazole-resistant Bacteroides fragilis wound infection. J.Infectol. 25, 211–214 (1992).

    Article  Google Scholar 

  • Oteo R., Aracil B., Aloe J.I., Gómez-Garces J.L.: High prevalence of resistance to clindamycin in Bacteroides fragilis group isolates. J.Antimicrob.Chemother. 45, 691–693 (2000).

    Article  CAS  PubMed  Google Scholar 

  • Phillips I., King A., Nord C.E., Hoffstedt B.: Antibiotic sensitivity of the Bacteroides fragilis group in Europe. Eur.J.Clin.Microbiol. Infect.Dis. 11, 292–304 (1992).

    Article  CAS  PubMed  Google Scholar 

  • Podglajen J., Breuil J., Collatz E.: Insertion of a novel DNA sequence, IS1186 upstream of the silent carbapenemase general cfiA, promotes expresion of carbapenem resistance in clinical isolates of Bacteroides fragilis. Mol.Microbiol. 12, 105–114 (1994).

    Article  CAS  PubMed  Google Scholar 

  • Ross J.I., Eady E.A., Cove J.H., Jones C.E., Ratyal A.H., Miller Y.W., Vyakrnam S., Cunliffe W.J.: Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutation in 23S rRNA. Antimicrob.Agents Chemother. 41, 1162–1165 (1997).

    CAS  PubMed  Google Scholar 

  • Snydman D.R., Mcdermott L., Cuchural G.J. Jr., Hecht D.W., Iannini P.B., Harrell L.J., Jenkins S.G., O’Keefe J.P., Pierson C.L., Rihs J.D., Yu V.L., Finegold S.M., Gorbach S.L.: Analysis of trend in antimicrobial resistance patterns among clinical isolates of Bacteroides fragilis group species from 1990 to 1994. Clin.Infect.Dis. 23 (Suppl. 1), S54–S65 (1996).

    PubMed  Google Scholar 

  • Snydman D.R., Jacobus N.V., McDermott L.A., Supran S., Cuchural J.G. Jr., Finegold S., Harrell L., Hecht D.W., Iannini P., Jenkins S., Pierson C., Rihs J., Gorbach S.L.: Multicenter study of in vitro susceptibility of the Bacteroides fragilis group with comparison of resistance trends from 1995 to 1996, with comparison of resistance trends from 1990 to 1996. Antimicrob.Agents Chemother. 43, 2417–2422 (1999).

    CAS  PubMed  Google Scholar 

  • Urbášková P.: Resistance of Bacteria toward Antibiotics. (InCzech) Trios Publishing, Prague 1997.

    Google Scholar 

  • Willis A.T., Ferguson J.R., Jones P.H.: Metronidazole in prevention and treatment of Bacteroides infections after appendicectomy. Brit.Med.J. 1, 318–321 (1976).

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Examination Methods and Medical Biology, Faculty of Health Studies, University of Ostrava, 703 00, Ostrava-Zábřeh, Czechia

    D. Chmelař

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Chmelař, D. In Vitro susceptibility to selected antibiotics in bacteria of the Bacteroides fragilis group. Folia Microbiol 54, 353–358 (2009). https://doi.org/10.1007/s12223-009-0050-5

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  • DOI: https://doi.org/10.1007/s12223-009-0050-5

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