Skip to main content
SpringerLink
Log in

Poly-ε-Caprolactone/Propolis Electrospun Yarns as Suture

  • Regular Article
  • Published:
Fibers and Polymers Aims and scope Submit manuscript

Abstract

Electrospinning is a well-known promising technique for the cost-effective and rapid fabrication of therapeutic-loaded nanofibers. Electrospun fibers have many merits that give them prospects in the production of therapeutic-loaded sutures. Despite the desirable properties of electrospun fibrous yarns, they have no prospective mechanical properties as a suture. Hence, improving the mechanical properties of the electrospun yarns is an open issue. This work applied electrospun composite mats consisting of poly-ε-caprolactone (PCL)/propolis ethanolic extract (PEE) with random and aligned morphological features of fibers to fabricate yarns. The PCL-PEE yarns were fabricated by twisting a ribbon-like part of these mats. Then, these yarns were characterized and evaluated as sutures. In vitro yarn release was followed during 221 h. Tensile testing of yarns was also studied. In addition, in vitro cell culture studies for the biocompatibility of MG-63 and human dermal fibroblast cells on the sutures and also antifungal and antibacterial effects of the sutures were assessed. These sutures were used for suturing an induced-wound rat model to follow in vivo effectiveness. Histopathological investigations were also done. Consequently, a PEE-PCL suture with elastomeric, mechanical, antibacterial, and antifungal properties and accelerated wound-healing features provides a proper and promising suture.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. M. Champeau, J.-M. Thomassin, T. Tassaing, C. Jérôme, Expert Opin. Drug Deliv. 14, 1293 (2017)

    CAS  PubMed  Google Scholar 

  2. C. Dennis, S. Sethu, S. Nayak, L. Mohan, Y. Morsi, G. Manivasagam, J. Mater. Res. A 104, 1544 (2016)

    CAS  Google Scholar 

  3. M. Tummalapalli, S. Anjum, S. Kumari, B. Gupta, Polym. Rev. 56, 607 (2016)

    CAS  Google Scholar 

  4. D. Madheswaran, M. Sivan, J. Valtera, E.K. Kostakova, T. Egghe, M. Asadian, V. Novotny, N.H.A. Nguyen, A. Sevcu, R. Morent, J. Appl. Polym. Sci. 139, 51851 (2022)

    CAS  Google Scholar 

  5. H. Liu, K.K. Leonas, Y. Zhao, J. Eng. Fiber. Fabr. 5, 155892501000500400 (2010)

    Google Scholar 

  6. M. Renko, N. Paalanne, T. Tapiainen, M. Hinkkainen, T. Pokka, S. Kinnula, J.-J. Sinikumpu, M. Uhari, W. Serlo, Lancet. Infect. Dis 17, 50 (2017)

    CAS  PubMed  Google Scholar 

  7. X. Ming, M. Nichols, S. Rothenburger, Surg. Infect. 8, 209 (2007)

    Google Scholar 

  8. S. Padmakumar, J. Joseph, M.H. Neppalli, S.E. Mathew, S.V. Nair, S.A. Shankarappa, D. Menon, ACS Appl. Mater. Interfaces. 8, 6925 (2016)

    CAS  PubMed  Google Scholar 

  9. K.Y. Win, S.-S. Feng, Biomaterials 26, 2713 (2005)

    CAS  PubMed  Google Scholar 

  10. Z. Gu, H. Yin, J. Wang, L. Ma, Y. Morsi, X. Mo, Colloids Surf., B 161, 331 (2018)

    CAS  Google Scholar 

  11. A. Luraghi, F. Peri, L. Moroni, J. Control Release 334, 463 (2021)

    CAS  PubMed  Google Scholar 

  12. B. Pant, M. Park, S.-J. Park, Pharmaceutics 11, 305 (2019)

    CAS  PubMed  PubMed Central  Google Scholar 

  13. R. Zelkó, D. A. Lamprou, I. Sebe, Recent development of electrospinning for drug delivery. MDPI (2019)

  14. D. Sharma, S. Dhingra, A. Banerjee, S. Saha, J. Bhattacharyya, B.K. Satapathy, Int. J. Biol. Macromol 216, 397 (2022)

    CAS  PubMed  Google Scholar 

  15. C.L. He, Z.M. Huang, X.J. Han, J. Biomed. Mater. Res. A 89, 80 (2009)

    PubMed  Google Scholar 

  16. A. Senthamizhan, B. Balusamy, T. Uyar, Electrospun materials for tissue engineering and biomedical applications (Elsevier, Amsterdam, 2017)

    Google Scholar 

  17. T.G. Darshan, C.-H. Chen, C.-Y. Kuo, K.T. Shalumon, Y.-M. Chien, H.-H. Kao, J.-P. Chen, Int. J. Biol. Macromol 221, 314 (2022)

    Google Scholar 

  18. P. Rivera, C. Villegas, R. Cabezas, B. Pérez, A. Torres, C. L. de Dicastillo, L. Garrido, P. Galvez, C. Araya, J. Romero, J. Supercrit. J Supercrit Fluids, 105854 (2023)

  19. E.-R. Kenawy, G.L. Bowlin, K. Mansfield, J. Layman, D.G. Simpson, E.H. Sanders, G.E. Wnek, J. Control Release 81, 57 (2002)

    CAS  PubMed  Google Scholar 

  20. J. Zeng, X. Xu, X. Chen, Q. Liang, X. Bian, L. Yang, X. Jing, J. Control Release 92, 227 (2003)

    CAS  PubMed  Google Scholar 

  21. K. Kim, Y.K. Luu, C. Chang, D. Fang, B.S. Hsiao, B. Chu, M. Hadjiargyrou, J. Control Release 98, 47 (2004)

    CAS  PubMed  Google Scholar 

  22. https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/60813/PARIKH-DISSERTATION-2017.pdf?sequence=1&isAllowed=y (2017)

  23. S.G. Kuntzler, J.A.V. Costa, M.G. de Morais, Int. J. Biol. Macromol 117, 800 (2018)

    CAS  PubMed  Google Scholar 

  24. P. Sinsup, V. Teeranachaideekul, A. Makarasen, L. Chuenchom, P. Prajongtat, S. Techasakul, P. Yingyuad, D. Dechtrirat, Membranes 11, 648 (2021)

    CAS  PubMed  PubMed Central  Google Scholar 

  25. G.K. Arbade, S. Jathar, V. Tripathi, T.U. Patro, Biomed. Phys. Eng. Express 4, 045011 (2018)

    Google Scholar 

  26. E. Sharifisamani, F. Mousazadegan, R. Bagherzadeh, M. Latifi, Polym. Eng. Sci. 60, 1520 (2020)

    CAS  Google Scholar 

  27. N. Akombaetwa, A. Bwanga, P.A. Makoni, B.A. Witika, Polymers 14, 2931 (2022)

    CAS  PubMed  PubMed Central  Google Scholar 

  28. M. Ranjbar-Mohammadi, V. Sa’di, M. Moezzi, R. Saghafi, Fibers Polym. 23, 1538 (2022)

    CAS  Google Scholar 

  29. J.E. Lee, S. Park, M. Park, M.H. Kim, C.G. Park, S.H. Lee, S.Y. Choi, B.H. Kim, H.J. Park, J.-H. Park, Acta Biomater. 9, 8318 (2013)

    CAS  PubMed  Google Scholar 

  30. W. Hu, Z.-M. Huang, X.-Y. Liu, Nanotechnology 21, 315104 (2010)

    PubMed  Google Scholar 

  31. A.E. Deliaert, E. Van den Kerckhove, S. Tuinder, S. Fieuws, J.H. Sawor, M.A. Meesters-Caberg, R.R. van der Hulst, J. Plast. Reconstr. Aesthet. Surg. 62, 771 (2009)

    PubMed  Google Scholar 

  32. A.S. Richard, R.S. Verma, Mater. Sci. Eng., C 128, 112334 (2021)

    CAS  Google Scholar 

  33. G.A. Burdock, Food Chem. Toxicol. 36, 347 (1998)

    CAS  PubMed  Google Scholar 

  34. Y.K. Park, S.M. Alencar, C.L. Aguiar, J. Agric. Food Chem. 50, 2502 (2002)

    CAS  PubMed  Google Scholar 

  35. P.G. Pietta, C. Gardana, A.M. Pietta, Fitoterapia 73, S7 (2002)

    CAS  PubMed  Google Scholar 

  36. V.D. Wagh, Adv Pharmacol Sci. (2013)

  37. T.B. Alberti, D.S. Coelho, M. de Prá, M. Maraschin, B. Veleirinho, J. Mater. Sci. 55, 9712 (2020)

    CAS  Google Scholar 

  38. N.K.H. Setty, M.S. Nagaraja, D.H. Nagappa, C.S. Giriyaiah, N.R. Gowda, R.D.M.L. Naik, IJMEDPH. 4 (2014)

  39. R. Mohamadinooripoor, S. Kashanian, P. Moradipour, S. Sajadimajd, E. Arkan, A. Tajehmiri, K. Rashidi, J. Polym. Res. 29, 1 (2022)

    Google Scholar 

  40. A. Blainski, G.C. Lopes, J.C.P. De Mello, Molecules 18, 6852 (2013)

    CAS  PubMed  PubMed Central  Google Scholar 

  41. A.T. Feldman, D. Wolfe, Histopathology (Springer, Berlin, 2014)

    Google Scholar 

  42. L. Xu, Y. Liu, W. Zhou, D. Yu, Polymers 14, 1637 (2022)

    CAS  PubMed  PubMed Central  Google Scholar 

  43. M.E. Pekdemir, M. Kök, I.N. Qader, Y. AydoĞDu, J. Polym. Res. 29, 109 (2022)

    CAS  Google Scholar 

  44. R. Augustine, S.K. Nethi, N. Kalarikkal, S. Thomas, C.R. Patra, J. Mater. Chem. B 5, 4660 (2017)

    CAS  PubMed  Google Scholar 

  45. K. Ghosal, A. Chandra, G. Praveen, S. Snigdha, S. Roy, C. Agatemor, S. Thomas, I. Provaznik, Sci. Rep. 8, 1 (2018)

    CAS  Google Scholar 

  46. A. Baji, Y.-W. Mai, S.-C. Wong, M. Abtahi, P. Chen, Compos. Sci. Technol. 70, 703 (2010)

    CAS  Google Scholar 

  47. Y. Zhu, N.H. Shah, A.W. Malick, M.H. Infeld, J.W. McGinity, Int. J. Pharm. 241, 301 (2002)

    CAS  PubMed  Google Scholar 

  48. C.L. Rabek, R.V. Stelle, T.D. Dziubla, D.A. Puleo, J. Biomater. Appl. 28, 779 (2014)

    CAS  PubMed  Google Scholar 

  49. M.A. Woodruff, D.W. Hutmacher, Prog. Polym. Sc. 35, 1217 (2010)

    CAS  Google Scholar 

  50. S. Martinotti, E. Ranzato, Burns Trauma 3, 1 (2015)

    Google Scholar 

  51. M. Stojko, J. Włodarczyk, M. Sobota, P. Karpeta-Jarząbek, M. Pastusiak, H. Janeczek, P. Dobrzyński, G. Starczynowska, A. Orchel, J. Stojko, Pharmaceutics 12, 883 (2020)

    CAS  PubMed  PubMed Central  Google Scholar 

  52. I. Przybyłek, T.M. Karpiński, Molecules 24, 2047 (2019)

    PubMed  PubMed Central  Google Scholar 

  53. J.C. Silva, S. Rodrigues, X. Feás, L.M. Estevinho, Food Chem. Toxicol. 50, 1790 (2012)

    CAS  PubMed  Google Scholar 

  54. E.C. De Almeida, H. Menezes, J. Venomous Anim. Toxins 8, 191 (2002)

    Google Scholar 

  55. T. Farooqui, A.A. Farooqui, Curr. Nutr. Food Sci. 6, 186 (2010)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Chemistry, Razi University, Kermanshah, Iran

    Rezvan Mohamadinooripoor & Soheila Kashanian

  2. Department of Nanobiotechnology, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

    Soheila Kashanian

  3. Biosensor Research Center, Endocrinology and Metabolism Molecular–Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Kobra Omidfar

  4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Kobra Omidfar

Authors
  1. Rezvan Mohamadinooripoor
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Soheila Kashanian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kobra Omidfar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Soheila Kashanian.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mohamadinooripoor, R., Kashanian, S. & Omidfar, K. Poly-ε-Caprolactone/Propolis Electrospun Yarns as Suture. Fibers Polym 24, 2641–2651 (2023). https://doi.org/10.1007/s12221-023-00257-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12221-023-00257-x

Keywords

Search

Navigation