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Investigation of Keratin/Poly(ethylene oxide) Nanofiber Membrane Prepared with Different Post-crosslinking Method

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Abstract

Post-crosslinking treatment is essential for improving the water tolerance of the electrospinning keratin/Poly(ethylene oxide) (PEO) nanofiber membrane to meet the requirement of the biomedical application. In this study, three ecofriendly low-cost methods, hot air, pure oxygen, and ultraviolet irradiation were employed as the post-crosslinking treatment to prepare the electrospun keratin/PEO (90/10) nanofiber membrane with good water tolerant. A comparative study between the performances of the nanofiber prepared by different cross-linking methods were carried out. The results showed the three post-crosslinking methods were all effective for transforming the water-soluble keratin/PEO nanofiber membranes to the water insoluble membranes. However, the mechanical property, water sorption and swelling rate, molecular structure, thermal property, and crystallinity of the nanofiber membranes were all different due to the different post-crosslinking methods. After heat treatment, the tensile strength of the nanofiber membrane can reach 2.29 MPa, while that of the oxygen crosslinking and ultraviolet crosslinking are 0.99 and 1.68 MPa, respectively. The water absorption and swelling of the oxygen and ultraviolet crosslinking membranes are relatively large, and the swelling rate is about 21%. The oxygen crosslinking membrane possessed higher hydrophilicity and the contact angle is only 21°. In vitro cell culture studies showed that the post-crosslinked nanofiber membrane all presented excellent biocompatibility and supported cell adhesion and proliferation. The three ecofriendly low-cost post-crosslinking treatments are all reliable and safe to prepare keratin/PEO nanofiber membrane with good water tolerant, which is potential for tissue engineering and biomedical applications.

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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This work was supported by the Tianjin Research Innovation Project for Postgraduate Students (No. 2021YJSB230) and the Industry-University Cooperative Education Program of the Ministry of Education (No.BINTECH-KJZX-20220831-22). We would like to thank to the Analytical & Testing Center of Tiangong University for emission scanning electron microscopy, Fourier Transform Infrared spectroscopy, X-ray diffraction and TG tests analysis work.

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Authors and Affiliations

  1. School of Textiles Science and Engineering, Tiangong University, Binshui West Road 399, Xiqing Distinct, Tianjin, 300387, China

    Jiahan Yang, Tongda Lei, Xue Yang, Jie Fan & Yong Liu

  2. Ministry of Education Key Laboratory of Advanced Textile Composite Materials, Tiangong University, Binshui West Road 399, Xiqing Distinct, Tianjin, 300387, China

    Jie Fan & Yong Liu

  3. Central Laboratory, Tianjin Beichen Hospital, Tianjin, China

    Huancheng Wu

  4. Department of Osteoarthritis, Tianjin Beichen Hospital, Tianjin, China

    Sen He

  5. School of Environmental Science and Engineering, Tiangong University, Binshui West Road 399, Xiqing Distinct, Tianjin, 300387, China

    Wei Liu

  6. State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes, Tiangong University, Binshui West Road 399, Xiqing Distinct, Tianjin, 300387, China

    Wei Liu

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  1. Jiahan Yang
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Correspondence to Jie Fan or Yong Liu.

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Yang, J., Lei, T., Yang, X. et al. Investigation of Keratin/Poly(ethylene oxide) Nanofiber Membrane Prepared with Different Post-crosslinking Method. Fibers Polym 24, 715–727 (2023). https://doi.org/10.1007/s12221-023-00078-y

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  • DOI: https://doi.org/10.1007/s12221-023-00078-y

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