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Biocompatibility of Polyimide Fibers with Human Gastric Cells In Vitro

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Abstract

The selection of calibration materials and methods is of great significance, since accurate localization of intragastric lesions is crucial for diagnosis and post-treatment follow-up of gastric cancer. In this study, a novel suturing calibration method was adopted using polyimide (PI) fibers with outstanding comprehensive properties as the calibration material. The acid resistance in vitro of PI fibers and biocompatibility to MGC-803 human gastric cancer cells were investigated. In the simulated gastric acid erosion environment, the color of PI fibers remained to be bright yellow and the tensile strength maintained at 1.09 GPa without degradation of chemical structure. Moreover, PI fibers possessed high crystallinity, smooth surface as well as high-oriented fractured morphologies, and exhibited excellent structural and property resistance to simulated gastric acid, which was responsible for the biocompatibility. PI fibers showed no influence on the viability, morphology or lactate dehydrogenase level of gastric cells through direct and indirect extract contact. Therefore, PI fibers showed good stability in simulated gastric acid and were not cytotoxic to human gastric cells, suggesting their utility as markers of intragastric lesions.

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Authors and Affiliations

  1. Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China

    Xiaoyue Wang & Jie Zhang

  2. Department of Pharmacology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China

    Jianwei Gao

Authors
  1. Xiaoyue Wang
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  2. Jianwei Gao
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  3. Jie Zhang
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Correspondence to Jie Zhang.

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Wang, X., Gao, J. & Zhang, J. Biocompatibility of Polyimide Fibers with Human Gastric Cells In Vitro. Fibers Polym 22, 2380–2387 (2021). https://doi.org/10.1007/s12221-021-0199-3

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  • DOI: https://doi.org/10.1007/s12221-021-0199-3

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