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PVA/PVP K90 Nanofibers Containing Punica granatum Peel Extract for Cosmeceutical Purposes

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Abstract

This study aimed to develop, characterize, and investigate the cosmeceutical activities and irritation properties of Punica granatum peel extract (PE) loaded nanofibers. Nanofibers from polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP K90) were prepared using an electrospinning technique and characterized by scanning electron microscope, Fourier transform infrared spectroscopy, X-ray diffractometer, differential scanning calorimeter, and tensile tester. The content of PE loaded in nanofibers were investigated using high-performance liquid chromatography. PE loaded nanofibers were investigated for antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assay. Anti-tyrosinase was determined by spectrophotometric method. The cytotoxicity and irritation properties were determined by WST-1-based cell cytotoxicity assay and hen’s egg test chorioallantoic membrane assay, respectively. The results remarked that 2.5 % w/v PE loaded in nanofiber containing 10 % w/v PVA and 2 % w/v PVP K90 (N2) were uniform with the mean diameter of 493.9±91.6 nm. The amorphous form of nanofibers was detected and around 94 % w/w of PE was entrapped. Additionally, N2 showed the most suitable mechanical properties and possessed the significantly highest antioxidant and anti-tyrosinase activities. Notably, it was safe since it had no cytotoxicity and no irritation. Therefore, PE loaded nanofibers were attractive and suggested for cosmeceutical applications.

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Acknowledgments

This research was funded by the National Research Council of Thailand, grant for the graduate student 2017; National Research Council of Thailand grant number P000019871; the Graduate School, Chiang Mai University, Thailand; and Faculty of Pharmacy, Chiang Mai University, Thailand.

The authors would like to thanks Dr. Sheng Qi and Prof. Emeritus Dr. Peter Belton, School of Pharmacy, University of East Anglia for support and encouragement.

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Authors and Affiliations

  1. Graduate School, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nachtharinee Laosirisathian

  2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nachtharinee Laosirisathian, Chalermpong Saenjum, Jakkapan Sirithunyalug, Wantida Chaiyana & Busaban Sirithunyalug

  3. Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, 50200, Thailand

    Jakkapan Sirithunyalug & Wantida Chaiyana

  4. Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand

    Sukum Eitssayeam

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  1. Nachtharinee Laosirisathian
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  2. Chalermpong Saenjum
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Correspondence to Wantida Chaiyana or Busaban Sirithunyalug.

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Laosirisathian, N., Saenjum, C., Sirithunyalug, J. et al. PVA/PVP K90 Nanofibers Containing Punica granatum Peel Extract for Cosmeceutical Purposes. Fibers Polym 22, 36–48 (2021). https://doi.org/10.1007/s12221-021-0165-0

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  • DOI: https://doi.org/10.1007/s12221-021-0165-0

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