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Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair

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Abstract

Growth factor-mediated healing of rotator cuff tendon requires to develop a clinically applicable biomaterial playing roles of mechanical support and growth factor release in vivo. In this study, the alginate (AG) nonwoven-sponge composite scaffold (AGNWSP) was fabricated through the formation of an AG sponge layer on the AG nonwoven scaffold (AGNW) surface, and rotator cuff repair with the AG-based scaffolds containing transforming growth factor-beta 1 (TGF-β1) was investigated with a rabbit model. AGNWSP had higher tensile strength, lower bioabsorbability, and higher sustained TGF-β1 release capacity than AGNW, which were highly correlated with tendon regeneration. AGNW and AGNWSP were fixed to the ruptured tendon-to-bone sites, and fresh solutions of TGF-β1 were injected into the scaffolds. When AGNWSP was applied, the repaired supraspinatus tendon had higher ultimate failure load and stress. In addition, well-organized collagen fibers and fibrocartilages were observed at the tendon-to-bone interface in this case. It is suggested that high degree of ruptured rotator cuff healing could be achieved with AGNWSP in combination with TGF-β1.

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Acknowledgements

This work was supported by the Technology Innovation Program (10062289) funded by the Ministry of Trade, Industry & Energy of Korea, and by the Government-wide R&D Fund Project for Infectious Disease Research (GFID) (grant number: HG19C0707), Republic of Korea.

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Authors and Affiliations

  1. Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu, 41566, Korea

    Ga Young Park & Jin Hyun Choi

  2. Department of Orthopaedic Surgery, School of Medicine, Kyungpook National University, Daegu, 41944, Korea

    Jong Pil Yoon

  3. Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, 41940, Korea

    Jong Pil Yoon & Jin Hyun Choi

Authors
  1. Ga Young Park
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  2. Jong Pil Yoon
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  3. Jin Hyun Choi
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Correspondence to Jin Hyun Choi.

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Park, G.Y., Yoon, J.P. & Choi, J.H. Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair. Fibers Polym 21, 1879–1887 (2020). https://doi.org/10.1007/s12221-020-9771-5

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  • DOI: https://doi.org/10.1007/s12221-020-9771-5

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