Fibers and Polymers

, Volume 17, Issue 11, pp 1749–1756 | Cite as

Development and characterization of alginate-chitosan-hyaluronic acid (ACH) composite fibers for medical applications

  • Tanveer Hussain
  • Rashid Masood
  • Muhammad Umar
  • Tanzeel Areeb
  • Azeem Ullah


Natural materials and plants have a long history of medical applications due to their broad range of favorable biological functions including biocompatibility, anti-bacterial, anti-oxidant and anti-inflammatory properties. Main objective of this study was to develop alginate-chitosan-hyaluronic acid (ACH) composite fibers with controlled drug release, and liquid retention properties for better moist wound healing. The dope comprising sodium alginate was extruded into calcium chloride (CaC12) coagulation bath. The developed calcium alginate fibers were then passed through a bath containing hydrolyzed chitosan and dip coated with hyaluronic acid for 24 hours. The resulting ACH composite fibers were then rinsed with deionized water and dried using acetone. These fibers were tested for tensile properties, % swelling, liquid absorption (g/g) and controlled drug release. The results concluded that ACH composite fibers can be produced by wet spinning and have adequate tensile properties, high % swelling, liquid absorption (g/g) and controlled release of hyaluronic acid for improved wound healing.


Hyaluronic acid Chitosan Alginate Wound care Absorption Controlled release 


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  1. 1.
    I. R. Sweeney, M. Miraftab, and G. Collyer, Carbohydr. Polym., 102, 920 (2014).CrossRefGoogle Scholar
  2. 2.
    S. Mizrahy and D. Peer, Chem. Soc. Rev., 41, 2623 (2012).CrossRefGoogle Scholar
  3. 3.
    V. R. Sinha and R. Kumria, Int. J. Pharma., 224, 19 (2001).CrossRefGoogle Scholar
  4. 4.
    Y. Ji, K. Ghosh, X. Z. Shu, B. Li, J. C. Sokolov, G. D. Prestwich, R. A. Clark, and M. H. Rafailovich, Biomaterials, 27, 3782 (2006).CrossRefGoogle Scholar
  5. 5.
    C. Jou, L. Yuan, S. Lin, M. Hwang, W. Chou, D. Yu, and M. Yang, J. Appl. Polym. Sci., 104, 16 (2006).Google Scholar
  6. 6.
    Y. Qin, Appl. Polym. Sci., 100, 2516 (2006).CrossRefGoogle Scholar
  7. 7.
    D. Raafat, K. V. Bargen, A. Haas, and H. Sahl, Appl. Environ. Microbiol., 74, 3746 (2008).CrossRefGoogle Scholar
  8. 8.
    T. Tsai, H. Chien, T. Wang, C. T. Huang, Y. B. Ker, and C. T. Chen, Antimicrob. Agents Ch., 55, 1883 (2011).CrossRefGoogle Scholar
  9. 9.
    A. Zamani and M. Taherzadeh, Bioresource, 5, 1554 (2010).Google Scholar
  10. 10.
    W. Steplewski, D. Wawro, and A. Niekraszewicz, Fibres Text. Easten Eur., 14, 25 (2006).Google Scholar
  11. 11.
    N. Maeda, J. Miao, T. J. Simmons, J. S. Dordick, and R. J. Linhardt, Carbohydr. Polym., 102, 950 (2014).CrossRefGoogle Scholar
  12. 12.
    A. S. Mehta, B. K. Singh, and P. K. Dutta, Asian Chit. J., 10, 25 (2014).Google Scholar
  13. 13.
    S. Yamane, N. Iwasaki, Y. Kasahara, K. Harada, T. Majima, K. Monde, S. Nishimura, and A. Minami, J. Biomed. Mater. Res. Part A, 81, 586 (2007).CrossRefGoogle Scholar
  14. 14.
    J. J. Ahire, D. Robertson, D. P. Neveling, A. J. van Reenen, and L. M. T. Dicks, RSC Adv., 4, 34791 (2016).CrossRefGoogle Scholar
  15. 15.
    Textiles, Fibers, BS EN ISO 5079:1996 (1996).Google Scholar
  16. 16.
    R. Masood and M. Miraftab, J. Wound Care, 23, 153 (2014).CrossRefGoogle Scholar
  17. 17.
    J. M. Song, J. H. Im, J. H. Kang, and J. D. Kang, Carbohydr. Polym., 78, 633 (2009).CrossRefGoogle Scholar
  18. 18.
    F. Nicola, J. Biol. Chem., 220, 303 (1956).Google Scholar
  19. 19.
    C. Knill, J. Kennedy, J. Mistry, M. Miraftab, G. Smart, M. R. Groocock, and H. J. Williams, Carbohydr. Polym., 55, 65 (2004).CrossRefGoogle Scholar
  20. 20.
    M. A. Xianpeng, J. Xiujian, and Z. Yunz, CN Patent, 102489193 (2012).Google Scholar
  21. 21.
    J. Necas, L. Bartosikova, P. Brauner, and J. Kolar, Vet Med. (Praha), 53, 397 (2008).Google Scholar
  22. 22.
    G. L. Xueping, CN Patent, 1748569 (2006).Google Scholar

Copyright information

© The Korean Fiber Society and Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Tanveer Hussain
    • 1
  • Rashid Masood
    • 2
  • Muhammad Umar
    • 2
  • Tanzeel Areeb
    • 2
  • Azeem Ullah
    • 3
  1. 1.Faculty of Engineering and TechnologyNational Textile UniversityFaisalabadPakistan
  2. 2.National Textile Research CentreNational Textile UniversityFaisalabadPakistan
  3. 3.Department of Materials and TestingNational Textile UniversityFaisalabadPakistan

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