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Electrospun egg albumin-PVA nanofibers containing tetracycline hydrochloride: Morphological, drug release, antibacterial, thermal and mechanical properties

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Abstract

In this study, electrospun egg albumin-poly(vinyl alcohol) (PVA/EA) nanofibrous samples containing tetracycline hydrochloride (TC-HCl) were prepared. The performance of EA loaded PVA nanofibers for controlled release of TC-HCl was investigated by SEM, ATR-FTIR and UV-vis spectrophotometry. Afterwards, the antibacterial, thermal and mechanical properties were carried out for these samples. The obtained results from SEM micrograph images showed that the simultaneous use of EA protein and TC-HCl antibiotic in the electrospun PVA samples led to a uniform and smooth fibers with an average diameter of about 590 nm. The ATR-FTIR spectrum proved the effect of EA on the PVA molecular chains by representing characteristic peaks located at 700–850 cm−1 and 3285 cm−1 wavenumbers corresponding to -NH2 and -NH-groups, respectively. The UV-vis results indicated a gradual and controlled TC-HCl release from the PVA/EA nanofibrous samples. Also, the difference between antibacterial inhibition zones around the samples confirmed the drug release results. Furthermore, the DSC thermograms exhibited the amorphous status of TC-HCl did not change while incorporated into the PVA nanofibrous samples. Finally, the mechanical properties of the samples demonstrated the key role of EA as a brittleness agent in PVA fibers.

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Authors and Affiliations

  1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 11155-4563, Iran

    Payam Zahedi & Mahshid Fallah-Darrehchi

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  1. Payam Zahedi
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  2. Mahshid Fallah-Darrehchi
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Correspondence to Payam Zahedi.

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Zahedi, P., Fallah-Darrehchi, M. Electrospun egg albumin-PVA nanofibers containing tetracycline hydrochloride: Morphological, drug release, antibacterial, thermal and mechanical properties. Fibers Polym 16, 2184–2192 (2015). https://doi.org/10.1007/s12221-015-5457-9

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  • DOI: https://doi.org/10.1007/s12221-015-5457-9

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