Sustained broad-spectrum antimicrobial and haemostatic chitosan-based film with immerged tea tree oil droplets
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- Ge, Y. & Ge, M. Fibers Polym (2015) 16: 308. doi:10.1007/s12221-015-0308-2
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For ideal wound-healing dressings, the chitosan-based films loaded with tea tree oil droplets were successfully fabricated by solution casting method. Tea tree oil emulsion droplets of about 200–300 nm in size were dispersed and immersed in chitosan films. Fourier transform infrared spectroscopy and differential scanning calorimetry measurement illustrated that the hydrogen-bonding interaction was formed between the amino and hydroxyl groups of chitosan and the hydroxyl groups of tea tree oil components to destroy the original hydrogen bond between chitosan molecules and change the physico-chemical properties of the films. With the increasing ratio of chitosan to tea tree oil, fluid absorption gradually decreased and water vapor permeability increased. The film with chitosan/tea tree oil ratio of 20:4 had identical hemostatic effect and non-cytotoxicity, and showed sustained growth inhibitory effect against S. aureus, E. coli and C. albicans. These results suggested that tea tree oil droplets played an important role in antimicrobial films and had a good potential to be incorporated into chitosan-based films which can be used in wound healing applications.