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Polyelectrolyte multilayer coated nanofibrous mats: Controlled surface morphology and cell culture

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Abstract

We reported the controlled surface morphologies and the cell culture of polyelectrolyte multilayer coated nylon 6 fibrous mats with different number of layers. Polyelectrolyte multilayer coated nylon 6 fibers were successfully prepared by an alternative deposition of alginic acid sodium salt and chitosan via a Layer-by-Layer (LbL) electrostatic self-assembly. The surface morphology, stiffness, and hydrophilicity of polyelectrolyte multilayer coated nylon 6 fibrous mats could be finely tuned by regulating the number of polyelectrolyte nanocoating. It was observed that the morphology of polyelectrolyte multilayer coated nylon 6 fibers was uniform and smooth, indicating a dense and harder nanocoating of polyelectrolytes onto nylon 6 fibers. Compared to pure nylon 6 fibrous mat (tensile strength ∼10.6±1 MPa), the tensile strength of polyelectrolyte coated nylon 6 fibrous mats was largely increased to 35.2±2 MPa for 5 bilayers coated fiber mats. In addition, it was found that at an initial stage after 1 day of cell culturing, the electrospun nylon 6 fibrous mats coated with 5 bilayer of alginic acid and chitosan show the highest cell affinity (good adhesion), while the electrospun nylon 6 fibrous mats coated with 10 bilayer show the lowest cell affinity. After cell seeding for 3 days, it was observed that rate of proliferation is enhanced by increasing the number of bilayer up to 3 bilayers (good proliferation), and then drastically decreased with further increasing the number of bilayer.

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Authors and Affiliations

  1. Department of Textile Engineering, Chonbuk National University, Jeonju, 561-756, Korea

    Jong Hoon Park, Hak Yong Kim & Myung Seob Khi

  2. Faculty of Textile Science and Technology, Shinshu University, Nagano, 386-8567, Japan

    Byoung Suhk Kim

  3. College of Veterinary Medicine, Chonbuk National University, Jeonju, 561-756, Korea

    Hyun Jin Tae & In Shik Kim

Authors
  1. Jong Hoon Park
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  2. Byoung Suhk Kim
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  3. Hyun Jin Tae
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  4. In Shik Kim
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  5. Hak Yong Kim
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  6. Myung Seob Khi
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Correspondence to Myung Seob Khi.

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Park, J.H., Kim, B.S., Tae, H.J. et al. Polyelectrolyte multilayer coated nanofibrous mats: Controlled surface morphology and cell culture. Fibers Polym 10, 419–424 (2009). https://doi.org/10.1007/s12221-009-0419-8

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  • DOI: https://doi.org/10.1007/s12221-009-0419-8

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