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Microgravity Science and Technology

, Volume 25, Issue 1, pp 67–72 | Cite as

Relation Between Motility, Accelerated Aging and Gene Expression in Selected Drosophila Strains under Hypergravity Conditions

  • Paloma Serrano
  • Jack J. W. A. van Loon
  • F. Javier Medina
  • Raúl HerranzEmail author
Original Article

Abstract

Motility and aging in Drosophila have proven to be highly modified under altered gravity conditions (both in space and ground simulation facilities). In order to find out how closely connected they are, five strains with altered geotactic response or survival rates were selected and exposed to an altered gravity environment of 2g. By analysing the different motile and behavioural patterns and the median survival rates, we show that altered gravity leads to changes in motility, which will have a negative impact on the flies’ survival. Previous results show a differential gene expression between sessile samples and adults and confirm that environmentally-conditioned behavioural patterns constrain flies’ gene expression and life span. Therefore, hypergravity is considered an environmental stress factor and strains that do not respond to this new environment experience an increment in motility, which is the major cause for the observed increased mortality also under microgravity conditions. The neutral-geotaxis selected strain (strain M) showed the most severe phenotype, unable to respond to variations in the gravitational field. Alternatively, the opposite phenotype was observed in positive-geotaxis and long-life selected flies (strains B and L, respectively), suggesting that these populations are less sensitive to alterations in the gravitational load. We conclude that the behavioural response has a greater contribution to aging than the modified energy consumption in altered gravity environments.

Keywords

Drosophila Motility Aging Altered gravity 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Paloma Serrano
    • 1
  • Jack J. W. A. van Loon
    • 1
    • 2
  • F. Javier Medina
    • 3
  • Raúl Herranz
    • 1
    • 3
    Email author
  1. 1.European Space Research & Technology Center–European Space Agency (ESTEC-ESA)NoordwijkNetherlands
  2. 2.Dutch Experiment Support Center (DESC) @ OCB-ACTAVU-University AmsterdamAmsterdamNetherlands
  3. 3.Centro de Investigaciones Biologicas (CSIC)MadridSpain

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