Abstract
Life on Earth has developed at unit gravity, 9.81 m/s2, which was a major factor especially when vertebrates emerged from water onto land in the late Devonian, some 375 million years ago. But how would nature have evolved on a larger planet? We are able to address this question simply in experiments using centrifuges. Based on these studies we have gained valuable insights in the physiological process in plants and animals. They adapt to a new steady state suitable for the high-g environments applied. Information on mammalian adaptations to hyper-g is interesting or may be even vital for human space exploration programs. It has been shown in long duration animal hypergravity studies, ranging from snails, rats to primates, that various structures like muscles, bones, neuro-vestibular, or the cardio-vascular system are affected. However, humans have never been exposed to a hyper-g environment for long durations. Centrifuge studies involving humans are mostly in the order of hours. The current work on human centrifuges are all focused on short arm systems to apply short periods of artificial gravity in support of long duration space missions in ISS or to Mars. In this paper we will address the possible usefulness of a large human centrifuge on Earth. In such a centrifuge a group of humans can be exposed to hypergravity for, in principle, an unlimited period of time like living on a larger planet. The input from a survey under scientists working in the field of gravitational physiology, but also other disciplines, will be discussed.
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Arlashchenko, N.I., Bokhov, B.B., Busygin, V.E., Volokhova, N.A., Grigoriev, Yu.G., Polyakov, B.I., Farber, Yu.V.: Body reactions to prolonged Coriolis acceleration. Translated from: Byulleten’ Eksperimental’ noi Biologii i Meditsiny. Bull. Eksp. Biol. Med. 55(8), 28–32 (1963) (translated)
Beams, H.W., Kessel, R.G.: Development of centrifuges and their use in the study of living cells. Int. Rev. Cytol. 100, 15–48 (1987)
Burton, R.R., Meeker, L.J., Raddin, J.H.: Centrifuges for studying the effects of sustained acceleration on human physiology. IEEE Eng. Med. Bio. 56–65 (1991), March
Cardus, D., McTaggart, W.G.: Artificial gravity as a countermeasure on physiological deconditioning in space. Adv. Space Res. 14(8), 409–414 (1994)
Clément, G., Pavy-Le Traon, A.: Centrifugation as a countermeasure during actual and simulated microgravity: a review. Eur. J. Physiol 92, 235–248 (2004)
Clément, G., Slenzka, K. (Eds.) Fundamentals of Space Biology: Research on Cells, Animals, and Plants in Space. Springer, New York (2006)
Convertino, V.A.: Interaction of semicircular canal stimulation with carotid baroreceptor reflex control of heart rate. J. Vestib. Res. 8(1), 43–9 (1998)
Davis, B.L., Cavanagh, P.R., Perry, J.E.: Locomotion in a rotating space station: a synthesis of new data with established concepts. Gait Posture 2, 157–65 (1994)
Edmonds, J.L., Jarchow, T., Young, L.R.: A stair-stepper for exercising on a short-radius centrifuge. Aviat. Space Environ. Med. 78(2), 129–34 (2007)
Gerathewohl, S.J. (Eds.) Space flight simulator. ABMA Rep. DSP-TR-1–59: dates 16 March 1959. Described In: Zero G. decvices and weightless simulators by NAS-NRC Publ. 781, 28–34 (1961)
Grigoriev, A.I., Morukov, B.V., Vorobiev, D.V.: Water and electrolyte studies during long-term missions onboard the space stations Salyut and Mir. Clin. Investig. 72, 169–89 (1994)
Hall, T.W.: Artificial gravity visualization, empathy and design. AIAA San Jose (CA), USA, paper 7321, pp. 1–22 (2006)
Hastreiter, D., Young, L.R.: Effects of a gravity gradient on human cardiovascular responses. J. Gravit. Physiol. 4(2), 23–26 (1997)
Hemmersbach, R., Volkmann, D., Hader, D.P.: Graviorientation in protists and plants. J. Plant Physiol. 154(1), 1–15 (1999)
Horneck, G., Facius, R., Rettberg, P., Reitz, G., Baumstark-Khan, C., Gerzer, R., Reichert, M., Seboldt, W., Manzey, D.: HUMEX study on the survivability and adaption of humans to long-duration exploratory missions. Edt.: R.A. Harris. ESA SP1264. Noordwijk, The Netherlands (2003)
Iwasaki, K., Hirayanagi, K.I., Sasaki, T., Kinoue, T., Ito, M., Miyamoto, A., Igarashi, M., Yajima, K.: Effects of repeated long duration +2Gz load on man’s cardiovascular function. Acta Astronaut. 42(1–8), 175–83 (1998)
Johnston, R.S., Dietlein, L.F. (eds.): Biomedical results from Skylab. Washington, DC: NASA SP-377 (1977)
Lackner, J.R., DiZio, P.: Artificial gravity as a countermeasure in long-duration space flight. J. Neurosci. Res. 62, 169–72 (2000)
Lansberg, M.P.: A Primer of Space Medicine. Elsevier Publishing Co. Amsterdam (1960)
Lansdorp, B., Kruijff, M., Heide, E.J., van der.: The need for MARS-g in LEO, IAC-03-IAA-10.1.05, pp. 1–8 (2003)
Manzey, D.: Human missions to Mars: new psychological challenges and research issues. Acta Astronaut. 55(3–9), 781–90 (2004)
Miles, S.: The effect of changes in barometric pressures on maximum breathing capacity. Am. J. Physiol. 137, 85–6 (1957)
NASA workshop: Artificial gravity. Live-aboard studies workshop. NASA-Ames, USA, (2005) 14–15 June
Newsom, B.D.: Habitability factors in a rotating space station. Space Life Sci. 3, 192–97 (1972)
Olson, J.J.: Antartica: a review of recent medical research. Trends Pharmacol. Sci. 23(10), 17–19 (2002)
Palinkas, L.A.: Phychological issues in long-term space flight: overview. Grav. Space Biol. Bull. 14(2), 25–33 (2001)
Pancratz, D.J., Bomar, J.B. Jr, Raddin, J.H. Jr.: A new source for vestibular illusions in high agility aircraft. Aviat. Space Environ. Med. 65(12), 1130–3 (1994)
Pawelczyk, J.A.: J. Physiol. 572(3), 607–608 (2006)
Pedoto, A., Nandi, J., Yang, Z.-J., et al.: Beneficial effect of hyperbaric oxygen pretreatment on lipopoly saccharide-induced shock in rats. Clin. Exp. Pharmacol. Physiol. 30(7), 482–488 (2003)
Ravera, R.J.: Physiological limits on Skylab B wobble during an artificial gravity experiment. NASA-CR-113979, pp. 1–12 (1970)
Reason, J.T., Graybiel, A.: Progressive adaptation to Coriolis accelerations associated with one rpm increments of velocity in the slow-rotation room. Aerosp. Med. 41(1), 73–79 (1970)
Sawka, M.N., Latzka, W.A., Mountain, S.J., Cadarette, B.S., Kolka, M.A., Kraning, K.K., Gonzalez, R.R.: Physiological tolerance to uncompensable heat, intermittent exercise, field vs. laboratory. Physiol. Med. Sci. Sports Exerc. 33, 422–430 (2001)
Scott, J.M., Esch, B.T., Goodman, L.S., Bredin, S.S., Haykowsky, M.J., Warburton, D.E.: Cardiovascular consequences of high-performance aircraft maneuvers: implications for effective countermeasures and laboratory-based simulations. Appl. Physiol. Nutr. Metab. 32(2), 332–9 (2007)
Singh, B.: Worldwide Human Centrifuge Status. The +Gzette. Publication of the International Acceleration Research Workshop Community. 5(1), 17–19 (2005)
Solonin, Yu.G., Katsyuba, E.A.: Thermoregulation and blood circulation in adults during short-term exposure to extreme temperatures. Hum. Physiol. 29(2), 188–94 (2003)
Tou, J., Ronca, A., Grindeland, R., Wade, C.: Models to study gravitational biology of Mammalian reproduction. Biol. Reprod. 67(6), 1681–7 (2002)
van Loon, J.J.W.A., Tanck, E., van Nieuwenhoven, F.A., Snoeckx, L.H.E.H., de Jong, H.A.A., Wubbels, R.J.: A brief overview of animal hypergravity studies. J. Gravit. Physiol. 12(1), 5–10 (2005)
Wade, C.E.: Responses across the gravity continuum: hypergravity to microgravity. Adv. Space Biol. Med. 10, 225–45 (2005)
Warren, L.E, Paloski, W.H., Young, L.R.: Artificial gravity as a multi-system countermeasure to bed rest deconditioning: preliminary results. 22nd ASGSB Annual Meeting, Arlington (VA), USA (2006) 2–5 November
Wunder C.C., L.O. Lutherer, C.H. Dodge.: Survival and growth of organisms during life-long exposure to high gravity. Aerospace Med. 5–11 (1963) March
Wuyts, F.: Preliminary experience with the ESA short arm human centrifuge. ELGRA News (2007) 25 Sept.
Young, L.R.: Artificial Gravity Considerations for a Mars Exploration Mission. Ann. N. Y. Acad. Sci. 871, 367–378 (1999)
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van Loon, J.J.W.A. The Human Centrifuge. Microgravity Sci. Technol 21, 203–207 (2009). https://doi.org/10.1007/s12217-008-9062-z
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DOI: https://doi.org/10.1007/s12217-008-9062-z