Skip to main content
Log in

Design of Micropump with two stacked ring type piezoelectric actuators for drug delivery

  • Research Article
  • Published:
Journal of Micro-Bio Robotics Aims and scope Submit manuscript

Abstract

The Micropump has many applications in the field of microfluidics systems where it has to handle a very small volume of fluids in a controlled manner. Applications include drug delivery and healthcare systems (Monitoring and diagnostic), microelectronic cooling devices, and many more. The main objective of this paper is to design a micropump for drug delivery applications with two Stacked ring type piezoelectric actuators (SPZT) for having a better flow rate with a low operating voltage of 90 VP-P. The Use of ring type actuator decreases the area of contact between actuator and membrane which has to be glued. A study is performed on membrane displacement by varying the inner radius of ring type SPZT actuator. The Actuator used here is the Stacked (multilayered) type which offers more strain at low voltages. All parametric study is performed using FEM numerical analysis. The proposed micropump design given a flow rate of 800(μl/min) at an operation frequency of 100 Hz.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15

Similar content being viewed by others

Availability of data and materials

There are no linked research data sets for this submission. The following reason is given: No data was used for the research described in the article.

References

  1. Dutse SW, Yusof NA (2011) Microfluidics-based lab-on-chip systems in DNA-based biosensing: an overview. Sensors 11(6):5754–5768

    Article  Google Scholar 

  2. Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26(11):1261–1268

    Article  Google Scholar 

  3. Marle L, Greenway GM (2005) Microfluidic devices for environmental monitoring. TrAC Trends Anal Chem 24(9):795–802

    Article  Google Scholar 

  4. Verpoorte E, De Rooij NF (2003) Microfluidics meets MEMS. Proc IEEE 91(6):930–953

    Article  Google Scholar 

  5. Capretto L, Cheng W, Hill M, Zhang X (2011) Micromixing within microfluidic devices. Microfluidics:27–68

  6. Sánchez-Ferrer A, Fischl T, Stubenrauch M, Albrecht A, Wurmus H, Hoffmann M, Finkelmann H (2011) Liquid-crystalline elastomer microvalve for microfluidics. Adv Mater 23(39):4526–4530

    Article  Google Scholar 

  7. Laser DJ, Santiago JG (2004) A review of micropumps. J Micromech Microeng 14(6):R35

    Article  Google Scholar 

  8. Rasmussen A, Mavriplis C, Zaghloul ME, Mikulchenko O, Mayaram K (2001) Simulation and optimization of a microfluidic flow sensor. Sensors Actuators A Phys 88(2):121–132

    Article  Google Scholar 

  9. Feng GH, Kim ES (2004) Micropump based on PZT unimorph and one-way parylene valves. J Micromech Microeng 14(4):429

    Article  Google Scholar 

  10. ----Bourouina, T., Bossebuf, A., & Grandchamp, J. P. (1997). Design and simulation of an electrostatic micropump for drug-delivery applications. J Micromech Microeng, 7(3), 186

  11. Yamahata C, Lotto C, Al-Assaf E, Gijs MAM (2005) A PMMA valveless micropump using electromagnetic actuation. Microfluid Nanofluid 1(3):197–207

    Article  Google Scholar 

  12. Chee PS, Minjal MN, Leow PL, Ali MSM (2015) Wireless powered thermo-pneumatic micropump using frequency-controlled heater. Sensors Actuators A Phys 233:1–8

    Article  Google Scholar 

  13. Merzouki T, Duval A, Zineb TB (2012) Finite element analysis of a shape memory alloy actuator for a micropump. Simul Model Pract Theory 27:112–126

    Article  Google Scholar 

  14. Chen CH, Santiago JG (2002) A planar electro osmotic micropump. J Microelectromech Syst 11(6):672–683

    Article  Google Scholar 

  15. Xu TB, Su J (2005) Development, characterization, and theoretical evaluation of electroactive polymer-based micropump diaphragm. Sensors Actuators A Phys 121(1):267–274

    Article  Google Scholar 

  16. Effenhauser CS, Harttig H, Krämer P (2002) An evaporation-based disposable micropump concept for continuous monitoring applications. Biomed Microdevices 4(1):27–32

    Article  Google Scholar 

  17. Colgate ED, Matsumoto H (1990) An investigation of electrowetting based microactuation. J Vac Sci Technol A 8(4):3625–3633

    Article  Google Scholar 

  18. Uvarov, I. V., Lemekhov, S. S., Melenev, A. E., Naumov, V. V., Koroleva, O. M., Izyumov, M. O., & Svetovoy, V. B. (2016, August). A simple electrochemical micropump: design and fabrication. In journal of physics: conference series (Vol. 741, no. 1, p. 012167). IOP publishing

  19. Geng X, Yuan H, Oguz HN, Prosperetti A (2001) Bubble-based micropump for electrically conducting liquids. J Micromech Microeng 11(3):270

    Article  Google Scholar 

  20. Darabi J, Ohadi MM, DeVoe D (2001) An electrohydrodynamic polarization micropump for electronic cooling. J Microelectromech Syst 10(1):98–106

    Article  Google Scholar 

  21. Zdeblick, M.J., Angell, J.B., A microminiature electric-to-fluidic valve. The 4thInternational Conference Solid State Sensors and Actuators (Transducer ‘87), Tokyo,827–829, 1987

  22. Smits JG (1990) Piezoelectric micropump with three valves working peristaltically. Sensors Actuators A Phys 21(1–3):203–206

    Article  Google Scholar 

  23. Wang B, Chu X, Li E, Li L (2006) Simulations and analysis of a piezoelectric micropump. Ultrasonics 44:e643–e646

    Article  Google Scholar 

  24. Cui Q, Liu C, Zha XF (2007) Study on a piezoelectric micropump for thecontrolled drug delivery system. Microfluid Nanofluidics 3(4):377–390

    Article  Google Scholar 

  25. Wang XY, Ma YT, Yan GY, Feng ZH (2014) A compact and high flow-ratepiezoelectric micropump with a folded vibrator. Smart Mater Struct 23(11):1–11

    Google Scholar 

  26. Singh S, Kumar N, George D, Sen AK (2015) Analytical modeling, simulationsand experimental studies of a PZT actuated planar valveless PDMS micropump. Sensors Actuators A Phys 225:81–94

    Article  Google Scholar 

  27. Rao KS, Ganesh GV, Lakshmi GS, Gopichand C, Sravani KG (2021) Analysis of PDMS based MEMS device for drug delivery systems. Microsyst Technol 27(3):659–664

    Article  Google Scholar 

  28. Rao KS, Ganesh GV, Lakshmi GS, Gopichand C, Sravani KG (2021) Analysis of PDMS based MEMS device for drug delivery systems. Microsyst Technol 27(3):659–664

    Article  Google Scholar 

  29. Rao, K. S., Sateesh, J., Guha, K., Baishnab, K. L., Ashok, P., \& Sravani, K. G. (2018). Design and analysis of MEMS based piezoelectric micro pump integrated with micro needle. Microsystem Technologies, 1–7

  30. Sateesh J, Sravani KG, Kumar RA, Guha K, Rao KS (2018) Design and flow analysis of MEMS based piezo-electric micro pump. Microsyst Technol 24(3):1609–1614

    Article  Google Scholar 

  31. Rao, K. S., Hamza, M., Kumar, P. A., \& Sravani, K. G. (2019). Design and optimization of MEMS based piezoelectric actuator for drug delivery systems. Microsystem Technologies, 1–9

  32. Revathi S, Padmanabhan R (2018) Design and development of PiezoelectricComposite-BasedMicropump. J Microelectromech Syst 27(6):1105–1113

    Article  Google Scholar 

  33. Dong S, Uchino K, Li L, Viehland D (2007) Analytical solutions for thetransverse deflection of a piezoelectric circular axisymmetric unimorph actuator. IEEE Trans Ultrason Ferroelectr Freq Control 54(6):1240–1249

    Article  Google Scholar 

  34. Nguyen, T.T., Pham, M., Goo, N.S., Development of a peristaltic micropumpfor bio-medical applications based on mini LIPCA. J. BionicEng.,5(2),135–141, 2008

  35. Chao C-S, Huang P-C, Chen M-K, Jang L-S (2011) Design and analysis of charge-recovery driving circuits for portable peristaltic micropumps with piezoelectric actuators. Sensors Actuators A Phys 168(2):313–319

    Article  Google Scholar 

  36. Stemme E, Stemme G (1993) A valveless diffuser/nozzle-based fluid pump. Sensors Actuators A Phys 39(2):159–167

    Article  Google Scholar 

  37. Forster FK, Bardell RL, Afromowitz MA, Sharma NR, Blanchard A (1995) Design, fabrication and testing of fixed-valve micro-pumps. ASMEPUBLICATIONS-FED 234:39–44

    Google Scholar 

  38. Cui, Q., Liu, C., Zha, X.F., Simulation and optimization of a piezoelectricmicropump for medical applications. Int J Adv Manuf Technol, 36(5–6), 516–524,2008

  39. Dong S, Bouchilloux P, Du XH, Uchino K (2001) Ring type uni/bimorph piezoelectric actuators. J Intell Mater Syst Struct 12(9):613–616

    Article  Google Scholar 

  40. H.M. Choi, S.K. Choi et. al. “Influence of film density on residual stress and resistivity for cu thin films deposited by bias sputtering.” Thin Solid Films 358 (2000) 202–205

  41. Choi HM, Choi SK, Anderson O, Bange K (2000) Influence of film density on residual stress and resistivity for cu thin films deposited by bias sputtering. Thin Solid Films 358(1–2):202–205

    Article  Google Scholar 

Download references

Acknowledgments

The authors would like to thank NMDC supported by NPMASS, Nationall Institute of Technology, Silchar for providing the necessary computational tools. We thank the anonymous referees for their useful suggestions.

Funding

The authors of the manuscript did not receive any funding, grants, or in kind support in support of the research or the preparation of the manuscript.

Author information

Authors and Affiliations

Authors

Contributions

Author 1,2 (K Girija Sravani, D Ramakrishna): Conceived and design the analysis, Contributed data and analysis tools, and wrote the paper. Author 3,4,5 (Prakash Chand,K.Satvik, K. Srinivasa Rao):Performed the analysis, Calibrated the results, Worked data analysis of the paper.

Corresponding author

Correspondence to Kondavitee Girija Sravani.

Ethics declarations

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

“Informed consent was obtained from all individual participants included in the study.”

Conflicts of interest

All authors have participated in (a) conception and design, or analysis and interpretation of the data; (b) drafting the article or revising it critically for important intellectual content; and (c) approval of the final version. This manuscript has not been submitted to, nor is under review at, another journal or other publishing venue. The authors have no affiliation with any organization with a direct or indirect financial interest in the subject matter discussed in the manuscript. The following authors have affiliations with organizations with direct or indirect financial interest in the subject matter discussed in the manuscript.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sravani, K.G., Ramakrishna, D., Chandh, P. et al. Design of Micropump with two stacked ring type piezoelectric actuators for drug delivery. J Micro-Bio Robot 17, 69–78 (2021). https://doi.org/10.1007/s12213-022-00146-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12213-022-00146-1

Keywords

Navigation