Cytotoxic activity of biosynthesized Ag Nanoparticles by Plantago major towards a human breast cancer cell line
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Silver nanoparticles were synthesized by bio-inspired route, a cost effective and fast synthesis method. Structural and morphological characterization of nanoparticles was performed by UV–visible absorption spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and transmission electron microscopy. The cytotoxic activity of both nanoparticles and Plantago major extract containing nanoparticles against a human breast cancer cell (MCF-7) was studied in vitro. MTT (3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays were performed using various concentrations of P. major extract (alone) and extract containing AgNPs ranging from 0.5 to 2.5 µg/ml. Data analysis showed significant level of cytotoxic activity. The potential cytotoxicity of silver nanoparticles in the treatment of breast cancer is discussed.
KeywordsCytotoxic Breast cancer Plantago major MTT Biosynthesis AgNPs
The authors thank Bam University of Medical Sciences, Bam, Iran.
The authors read and approved the final manuscript.
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Conflict of interest
The authors confirm that this article content has no competing interests.
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