Transactions of Tianjin University

, Volume 21, Issue 5, pp 383–391 | Cite as

Alginate-casein microspheres as bioactive vehicles for nutrients

  • Zhimin He (何志敏)
  • Xiqing Zhang (张茜青)
  • Wei Qi (齐 崴)Email author
  • Renliang Huang (黄仁亮)
  • Rongxin Su (苏荣欣)


The aim of this work was to develop an alginate-casein composite microsphere as a bioactive vehicle for oral administration of nutrients by a simple extrusion dripping method. Riboflavin was selected as a model drug, and the microencapsulation efficiency was raised to 97.94% after optimizing the preparation conditions by response surface methodology. In vitro release studies showed that riboflavin was released completely from alginate-casein microspheres in simulated intestinal fluids. Meanwhile, the morphology, structure and interaction between alginate and casein were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectra.


alginate casein microencapsulation response surface methodology bioactive peptides 


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Supplementary material

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Copyright information

© Tianjin University and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Zhimin He (何志敏)
    • 1
  • Xiqing Zhang (张茜青)
    • 1
  • Wei Qi (齐 崴)
    • 1
    • 2
    • 3
    Email author
  • Renliang Huang (黄仁亮)
    • 4
  • Rongxin Su (苏荣欣)
    • 1
    • 2
    • 3
  1. 1.State Key Laboratory of Chemical Engineering, School of Chemical Engineering and TechnologyTianjin UniversityTianjinChina
  2. 2.Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)TianjinChina
  3. 3.Tianjin Key Laboratory of Membrane Science and Desalination TechnologyTianjin UniversityTianjinChina
  4. 4.School of Environmental Science and EngineeringTianjin UniversityTianjinChina

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