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Preparation and evaluation of microcapsule containing volatile oil of Herba Schizonepetae by emulsion solvent diffusion method

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Abstract

Microcapsules of volatile oil containing Herba Schizonepetae (VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients. Orthogonal assay was applied to optimize the preparation condition of microcapsulation, and the results illustrated that the ratio of ethyl cellulose (EC) to VOHS influenced the property of VOHS microcapsule significantly. GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation. The microcapsules prepared with optimum condition had good fluidity, and the holes on the surface of the microcapsules contributed to the release of VOHS. The particles of the microcapsule conformed to a normal distribution with the diameter of 45–220 μm. In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate, pulegone in VOHS microcapsule showed a certain degree of slow release. Compared with β-cyclodextrin method, the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading. It was beneficial to reduce the dose of Chinese medicines containing volatile oils.

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Authors and Affiliations

  1. School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China

    Liguo Zhang  (张立国), Xiaowen Ouyang  (欧阳霄雯) & Lijun Ni  (倪力军)

  2. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200025, China

    Wanzhong Shi  (史万忠)

Authors
  1. Liguo Zhang  (张立国)
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  2. Xiaowen Ouyang  (欧阳霄雯)
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  3. Lijun Ni  (倪力军)
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  4. Wanzhong Shi  (史万忠)
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Corresponding author

Correspondence to Lijun Ni  (倪力军).

Additional information

Supported by the Plan Issue of Shanghai Science & Technology Committee (No. 13401901100).

Zhang Liguo, born in 1963, male, Dr, associate Prof.

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Zhang, L., Ouyang, X., Ni, L. et al. Preparation and evaluation of microcapsule containing volatile oil of Herba Schizonepetae by emulsion solvent diffusion method. Trans. Tianjin Univ. 20, 103–111 (2014). https://doi.org/10.1007/s12209-014-2182-1

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  • DOI: https://doi.org/10.1007/s12209-014-2182-1

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