Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is an emerging, non-invasive hyperthermia technology which can be used for the treatment of benign and malignant tumours, in conjunction with intracranial neurological diseases. To treat different indications, it is often necessary to design special focused ultrasound devices and treatment plans, which poses great challenges and results in substantial costs during software development. This article introduces a general software architecture that can be applied to three different focused ultrasound devices for the treatment of uterine fibroids, breast fibroids, and pain palliation of bone metastases, respectively, and can be integrated with GE Discovery or Signa MRI scanners and Xingaoyi BroadScan MRI scanners. Finally, the proposed software architecture was shown to possess desirable universality and safety through various tests and animal experimental studies.
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RIEKE V, BUTTS PAULY K. MR thermometry [J]. Journal of Magnetic Resonance Imaging, 2008, 27(2): 376–390.
KIM J H, HAHN E W. Clinical and biological studies of localized hyperthermia [J]. Cancer Research, 1979, 39(6 Pt 2): 2258–2261.
KENNEDY J E. High-intensity focused ultrasound in the treatment of solid tumours [J]. Nature Reviews Cancer, 2005, 5(4): 321–327.
COPELAN A, HARTMAN J, CHEHAB M, et al. High-intensity focused ultrasound: Current status for image-guided therapy [J]. Seminars in Interventional Radiology, 2015, 32(4): 398–415.
DEWHIRST M W, VIGLIANTI B L, LORA-MICHIELS M, et al. Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia [J]. International Journal of Hyperthermia, 2003, 19(3): 267–294.
SAPARETO S A, DEWEY W C. Thermal dose determination in cancer therapy [J]. International Journal of Radiation Oncology*Biology*Physics, 1984, 10(6): 787–800.
JOLESZ F A. MRI-guided focused ultrasound surgery [J]. Annual Review of Medicine, 2009, 60: 417–430.
SCHLESINGER D, BENEDICT S, DIEDERICH C, et al. MR-guided focused ultrasound surgery, present and future [J]. Medical Physics, 2013, 40(8): 080901.
HECTORS S J, JACOBS I, MOONEN C T, et al. MRI methods for the evaluation of high intensity focused ultrasound tumor treatment: Current status and future needs [J]. Magnetic Resonance in Medicine, 2016, 75(1): 302–317.
DE POORTER J, DE WAGTER C, DE DEENE Y, et al. Noninvasive MRI thermometry with the proton resonance frequency (PRF) method: In vivo results in human muscle [J]. Magnetic Resonance in Medicine, 1995, 33(1): 74–81.
MENG Y, SUPPIAH S, MITHANI K, et al. Current and emerging brain applications of MR-guided focused ultrasound [J]. Journal of Therapeutic Ultrasound, 2017, 5: 26.
GHANOUNI P, PAULY K B, ELIAS W J, et al. Transcranial MRI-guided focused ultrasound: A review of the technology and neuro applications [J]. American Journal of Roentgenology, 2015, 205(1): 150–159.
HURWITZ M D, ZAORSKY N G. Image-guided focused ultrasound for the treatment of bone metastases: Current status and future direction [J]. Current Radiology Reports, 2013, 1(2): 147–153.
GIANFELICE D, GUPTA C, KUCHARCZYK W, et al. Palliative treatment of painful bone metastases with MR imaging-guided focused ultrasound [J]. Radiology, 2008, 249(1): 355–363.
GOMBOS E C, KACHER D F, FURUSAWA H, et al. Breast focused ultrasound surgery with magnetic resonance guidance [J]. Topics in Magnetic Resonance Imaging, 2006, 17(3): 181–188.
HYNYNEN K, POMEROY O, SMITH D N, et al. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: A feasibility study [J]. Radiology, 2001, 219(1): 176–185.
CHAPMAN A, TER HAAR G. Thermal ablation of uterine fibroids using MR-guided focused ultrasound-a truly non-invasive treatment modality [J]. European Radiology, 2007, 17(10): 2505–2511.
HYNYNEN K. MRI-guided focused ultrasound treatments [J]. Ultrasonics, 2010, 50(2): 221–229.
ZUCCONI F, COLOMBO P E, PASETTO S, et al. Analysis and reduction of thermal dose errors in MRgFUS treatment [J]. Physica Medica, 2014, 30(1): 111–116.
ELLIS S, RIEKE V, KOHI M, et al. Clinical applications for magnetic resonance guided high intensity focused ultrasound (MRgHIFU): Present and future [J]. Journal of Medical Imaging and Radiation Oncology, 2013, 57(4): 391–399.
LOEVE A J, AL-ISSAWI J, FERNANDEZ-GUTIÉRREZ F, et al. Workflow and intervention times of MR-guided focused ultrasound: Predicting the impact of new techniques [J]. Journal of Biomedical Informatics, 2016, 60: 38–48.
HOKLAND S L, PEDERSEN M, SALOMIR R, et al. MRI-guided focused ultrasound: Methodology and applications [J]. IEEE Transactions on Medical Imaging, 2006, 25(6): 723–731.
LAPLANTE P A, NEILL C J, SANGWAN R S. Healthcare professionals’ perceptions of medical software and what to do about it [J]. Computer, 2006, 39(4): 26–32.
WALLACE D R, KUHN D R. Lessons from 342 medical device failures [C]//Proceedings 4th IEEE International Symposium on High-Assurance Systems Engineering. Washington, DC, USA: IEEE, 1999: 123–131.
FELDMANN R L, SHULL F, DENGER C, et al. A survey of software engineering techniques in medical device development [C]//2007 Joint Workshop on High Confidence Medical Devices, Software, and Systems and Medical Device Plug-and-Play Interoperability (HCMDSS-MDPnP 2007). Boston, MA, USA: IEEE, 2007: 46–54.
AMIRI A. St. Jude medical: An object-oriented software architecture for embedded and real-time medical devices [D]. San Luis Obispo, USA: California Polytechnic State University, 2010.
POORMAN M E, CHAPLIN V L, WILKENS K, et al. Open-source, small-animal magnetic resonance-guided focused ultrasound system [J]. Journal of Therapeutic Ultrasound, 2016, 4(1): 22.
We thank Shanghai General Hospital for the support of the animal trials. We thank Dr. ZONG Shenyan and Dr. WU Nan for review and revision of this article.
Foundation item: the National Natural Science Foundation of China (Nos. 81727806 and 11774231); the National Key Research and Development Program of Ministry of Science and Technology (No. 2017YFC0108900); the Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support—Gainers from Shanghai Jiao Tong University School of Medicine (No. 20152230); the Emerging Frontier Technology Joint Research Program of Shanghai Shen-Kang Hospital Development Center (No. SHDC2017127)
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Zhang, S., Tang, N., Shen, G. et al. Universal Software Architecture of Magnetic Resonance-Guided Focused Ultrasound Surgery System and Experimental Study. J. Shanghai Jiaotong Univ. (Sci.) 26, 471–481 (2021). https://doi.org/10.1007/s12204-021-2325-1
- magnetic resonance-guided focused ultrasound surgery (MRgFUS)
- software architecture
- focused ultrasound surgery workflow
- MRI thermometry
- R 454.5