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In-vitro and in-vivo electrical characteristics of a penetrating microelectrode array for optic nerve electrical stimulation

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Abstract

The Chinese C-Sight team aims to restore vision to blind patients by means of stimulating the optic nerve with a penetrating microelectrode array. A biocompatible, implantable microwire array was developed having four platinum-iridium shafts, each 100 μm in diameter. This penetrating microwire array is described in this paper, including its fabrication techniques and its in-vitro electrical characteristics. Every set of four shafts was spaced 0.4mm from center to center, comprising two short shafts that were 0.3mm long and two that were 0.9mm long. This design was intended to stimulate ganglion cell axons at different depths within the optic nerve. In-vitro electrochemical impedance testing results showed that the impedance at 1 kHz ranged from 8 to 10 kΩ at room temperature. The voltage responses of the arrays to current pulse stimulation indicated a charge-injection capacity of 210 μC/cm2. Finally, in-vivo acute animal experiments showed that the amplitude of the electrically evoked potentials (EEPs) measured in primary visual cortex could be as large as 100 μV upon direct stimulation of the optic nerve.

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Authors and Affiliations

  1. Institute of Laser Medicine and Biophotonics, Shanghai Jiaotong Universtiy, Shanghai, 200240, China

    Xiao-hong Sui  (隋晓红), Yi-bin Shao  (邵轶彬), Li-ming Li  (李丽明), Xin-yu Chai  (柴新禹) & Qiu-shi Ren  (任秋实)

  2. Department of Biomedical Engineering, Peking University, Beijing, 100871, China

    Qiu-shi Ren  (任秋实)

Authors
  1. Xiao-hong Sui  (隋晓红)
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  2. Yi-bin Shao  (邵轶彬)
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  3. Li-ming Li  (李丽明)
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  4. Xin-yu Chai  (柴新禹)
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  5. Qiu-shi Ren  (任秋实)
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Corresponding author

Correspondence to Qiu-shi Ren  (任秋实).

Additional information

Foundation item: the National Natural Science Foundation of China (Nos. 30700217 and 60971102) and the National Basic Research Program (973) of China (Nos. 2011CB707502 and 2011CB707505)

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Sui, Xh., Shao, Yb., Li, Lm. et al. In-vitro and in-vivo electrical characteristics of a penetrating microelectrode array for optic nerve electrical stimulation. J. Shanghai Jiaotong Univ. (Sci.) 16, 614–619 (2011). https://doi.org/10.1007/s12204-011-1198-0

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  • DOI: https://doi.org/10.1007/s12204-011-1198-0

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