Frontiers of Optoelectronics

, Volume 11, Issue 1, pp 23–29 | Cite as

Recent advances in photonic dosimeters for medical radiation therapy

Review Article
  • 15 Downloads

Abstract

Radiation therapy, which uses X-rays to destroy or injure cancer cells, has become one of the most important modalities to treat the primary cancer or advanced cancer. High resolution, water equivalent and passive X-ray dosimeters are highly desirable for developing quality assurance (QA) systems for novel cancer therapy like microbeam radiation therapy (MRT) which is currently under development. Here we present the latest developments of high spatial resolution scintillator based photonic dosimeters, and their applications to clinical external radiation beam therapies: specifically high energy linear accelerator (LINAC) photon beams and low energy synchrotron photon beams. We have developed optical fiber dosimeters with spatial resolutions ranging from 50 to 500 mm and tested them with LINAC beams and synchrotron microbeams. For LINAC beams, the fiberoptic probes were exposed to a 6 MV, 10 cm by 10 cm Xray field and, the beam profiles as well as the depth dose profiles were measured at a source-to-surface distance (SSD) of 100 cm. We have also demonstrated the possibility for temporally separating Cherenkov light from the pulsed LINAC scintillation signals. Using the 50 mm fiber probes, we have successfully resolved the microstructures of the microbeams generated by the imaging and medical beamline (IMBL) at the Australian Synchrotron and measured the peak-to-valley dose ratios (PVDRs). In this paper, we summarize the results we have achieved so far, and discuss the possible solutions to the issues and challenges we have faced, also highlight the future work to further enhance the performances of the photonic dosimeters.

Keywords

fiber-optic dosimetry scintillators X-ray Cherenkov radiation cancer therapy microbeam radiation therapy (MRT) 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

Acknowledgements

This project was supported by UOW’s Global Challenges Program. This research was undertaken on the Imaging and Medical beamline at the Australian Synchrotron, Victoria, Australia (AS162/ IMBL/10829). This research has been conducted with the support of the Australian Government Research Training Program Scholarship.

References

  1. 1.
    Leo W R. Techniques for Nuclear and Particle Physics. Berlin Heidelberg: Springer, 1994CrossRefGoogle Scholar
  2. 2.
    Čerenkov P A. Visible radiation produced by electrons moving in a medium with velocities exceeding that of light. Physical Review, 1937, 52(4): 378–379CrossRefGoogle Scholar
  3. 3.
    O’Keeffe S, McCarthy D, Woulfe P, Grattan MWD, Hounsell A R, Sporea D, Mihai L, Vata I, Leen G, Lewis E. A review of recent advances in optical fibre sensors for in vivo dosimetry during radiotherapy. The British Journal of Radiology, 2015, 88(1050): 20140702CrossRefGoogle Scholar
  4. 4.
    Aberle C, Elagin A, Frisch H J, Wetstein M, Winslow L. Measuring directionality in double-beta decay and neutrino interactions with kiloton-scale scintillation detectors. Journal of Instrumentation, 2014, 9: P06012CrossRefGoogle Scholar
  5. 5.
    Rusby D R, Brenner C M, Armstrong C, Wilson L A, Clarke R, Alejo A, Ahmed H, Butler N M H, Haddock D, Higginson A, McClymont A, Mirfayzi S R, Murphy C, Notley M, Oliver P, Allott R, Hernandez-Gomez C, Kar S, McKenna P, Neely D. Pulsed X-ray imaging of high-density objects using a ten picosecond highintensity laser driver. In: Proceedings of Emerging Imaging & Sensing Technologies. 2016, 9992: 99920ECrossRefGoogle Scholar
  6. 6.
    Deas R M, Wilson L A, Rusby D, Alejo A, Allott R, Black P P, Black S E, Borghesi M, Brenner C M, Bryant J, Clarke R J, Collier J C, Edwards B, Foster P, Greenhalgh J, Hernandez-Gomez C, Kar S, Lockley D, Moss R M, Najmudin Z, Pattathil R, Symes D, Whittle M D, Wood J C, McKenna P, Neely D. A laser driven pulsed X-ray backscatter technique for enhanced penetrative imaging. Journal of X-Ray Science and Technology, 2015, 23(6): 791–797CrossRefGoogle Scholar
  7. 7.
    Beddar A S, Mackie T R, Attix F H. Water-equivalent plastic scintillation detectors for high-energy beam dosimetry: 1. physical characteristics and theoretical considerations. Physics in Medicine & Biology, 1992, 37(10): 1883–1900CrossRefGoogle Scholar
  8. 8.
    Beddar A S, Mackie T R, Attix F H. Water-equivalent plastic scintillation detectors for high-energy beam dosimetry: 2. properties and measurements. Physics in Medicine & Biology, 1992, 37(10): 1901–1913CrossRefGoogle Scholar
  9. 9.
    Beaulieu L, Beddar S. Review of plastic and liquid scintillation dosimetry for photon, electron, and proton therapy. Physics in Medicine & Biology, 2016, 61(20): R305CrossRefGoogle Scholar
  10. 10.
    Shaffer T M, Pratt E C, Grimm J. Utilizing the power of Cerenkov light with nanotechnology. Nature Nanotechnology, 2017, 12(2): 106CrossRefGoogle Scholar
  11. 11.
    Andreozzi J M, Zhang R, Gladstone D J, Williams B B, Glaser A K, Pogue B W, Jarvis L A. Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy. Medical Physics, 2016, 43(2): 993–1002CrossRefGoogle Scholar
  12. 12.
    Vukolov A V, Novokshonov A I, Potylitsyn A P, Uglov S R. Electron beam diagnostics tool based on Cherenkov radiation in optical fibers. Journal of Physics Conference Series, 2016, 732 (1): 012011CrossRefGoogle Scholar
  13. 13.
    Boer S F D, Beddar A S, Rawlinson J A. Optical filtering and spectral measurements of radiation-induced light in plastic scintillation dosimetry. Physics in Medicine & Biology, 1993, 38(7): 945–958CrossRefGoogle Scholar
  14. 14.
    Clift M A, Sutton R A, Webb D V. Dealing with Cerenkov radiation generated in organic scintillator dosimeters by bremsstrahlung beams. Physics in Medicine & Biology, 2000, 45(5): 1165–1182CrossRefGoogle Scholar
  15. 15.
    Archambault L, Therriault-Proulx F, Beddar S, Beaulieu L. A mathematical formalism for hyperspectral, multipoint plastic scintillation detectors. Physics in Medicine & Biology, 2012, 57 (21): 7133–7145CrossRefGoogle Scholar
  16. 16.
    Therriault-Proulx F, Archambault L, Beaulieu L, Beddar S. Development of a novel multi-point plastic scintillation detector with a single optical transmission line for radiation dose measurement. Physics in Medicine & Biology, 2012, 57(21): 7147–7159CrossRefGoogle Scholar
  17. 17.
    Clift MA, Johnston P N, Webb D V. A temporal method of avoiding the Cerenkov radiation generated in organic scintillator dosimeters by pulsed mega-voltage electron and photon beams. Physics in Medicine & Biology, 2002, 47(8): 1421–1433CrossRefGoogle Scholar
  18. 18.
    Justus B L, Falkenstein P, Huston A L, Plazas M C, Ning H, Miller R W. Gated fiber-optic-coupled detector for in vivo real-time radiation dosimetry. Applied Optics, 2004, 43(8): 1663–1668CrossRefGoogle Scholar
  19. 19.
    Bouchet A, Lemasson B, Christen T, Potez M, Rome C, Coquery N, Le Clec'h C, Moisan A, Brauer-Krisch E, Leduc G, Remy C, Laissue J A, Barbier E L, Brun E, Serduc R. Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain. Radiotherapy and Oncology, 2013, 108(1): 143–148CrossRefGoogle Scholar
  20. 20.
    Crosbie J C, Anderson R L, Rothkamm K, Restall C M, Cann L, Ruwanpura S, Meachem S, Yagi N, Svalbe I, Lewis R A, Williams B R, Rogers P A. Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues. International Journal of Radiation Oncology, Biology, Physics, 2010, 77(3): 886–894CrossRefGoogle Scholar
  21. 21.
    Regnard P, Le Duc G, Brauer-Krisch E, Clair C, Kusak A, Dallery D, et al.. Microbeam radiation therapy (MRT) applied to rats ́brain tumor: finding the best compromise between normal tissue sparing and tumor curing. European Journal of Cancer Supplements, 2005, 3 (2): 396Google Scholar
  22. 22.
    Serduc R, Vérant P, Vial J C, Farion R, Rocas L, Rémy C, Fadlallah T, Brauer E, Bravin A, Laissue J, Blattmann H, van der Sanden B. In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature. International Journal of Radiation Oncology, Biology, Physics, 2006, 64(5): 1519–1527CrossRefGoogle Scholar
  23. 23.
    Smyth L M L, Senthi S, Crosbie J C, Rogers P A W. The normal tissue effects of microbeam radiotherapy: what do we know, and what do we need to know to plan a human clinical trial? International Journal of Radiation Biology, 2016, 92(6): 302–311CrossRefGoogle Scholar
  24. 24.
    Cornelius I, Guatelli S, Fournier P, Crosbie J C, Sanchez Del Rio M, Bräuer-Krisch E, Rosenfeld A, Lerch M. Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy. Journal of Synchrotron Radiation, 2014, 21(3): 518–528CrossRefGoogle Scholar
  25. 25.
    Fournier P, Cornelius I, Donzelli M, Requardt H, Nemoz C, Petasecca M, Bräuer-Krisch E, Rosenfeld A, Lerch M. X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy. Journal of Synchrotron Radiation, 2016, 23(5): 1180–1190CrossRefGoogle Scholar
  26. 26.
    Fournier P, Cornelius I, Dipuglia A, Cameron M, Davis J A, Cullen A, Petasecca M, Rosenfeld A B, Brauer-Krisch E, Häusermann D, Stevenson A W, Perevertaylo V, Lerch M L F. X-Tream dosimetry of highly brilliant X-ray microbeams in the MRT hutch of the Australian Synchrotron. Radiation Measurements, 2017 doi: 10.1016/j.radmeas.2017.01.011Google Scholar
  27. 27.
    Lerch M L F, Dipuglia A, Cameron M, Fournier P, Davis J, Petasecca M, Cornelius I, Perevertaylo V, Rosenfeld A B. New 3D silicon detectors for dosimetry in Microbeam Radiation Therapy. Journal of Physics Conference Series, 2017, 777(1): 012009CrossRefGoogle Scholar
  28. 28.
    Belley M D, Stanton I N, Hadsell M, Ger R, Langloss B W, Lu J, Zhou O, Chang S X, Therien M J, Yoshizumi T T. Fiber-optic detector for real time dosimetry of a micro-planar X-ray beam. Medical Physics, 2015, 42(4): 1966–1972CrossRefGoogle Scholar
  29. 29.
    Archer J, Li E, Petasecca M, Lerch M, Rosenfeld A, Carolan M. High-resolution fiber-optic dosimeters for microbeam radiation therapy. Medical Physics, 2017, 44(5): 1965–1968CrossRefGoogle Scholar
  30. 30.
    Archer J, Madden L, Li E, Carolan M, Petasecca M, Metcalfe P, Rosenfeld A. Temporally separating Cherenkov radiation in a scintillator probe exposed to a pulsed X-ray beam. Physica Medica, 2017, 42: 185–188CrossRefGoogle Scholar
  31. 31.
    Archer J, Li E, Petasecca M, Dipuglia A, Cameron M, Stevenson A, Hall C, Hausermann D, Rosenfeld A, Lerch M. X-ray microbeam measurements with a high resolution scintillator fibre-optic dosimeter. Scientific Reports, 2017, 7(1): 12450CrossRefGoogle Scholar

Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Centre for Medical Radiation PhysicsUniversity of WollongongWollongongAustralia

Personalised recommendations