Abstract
The Nuclear Age began in 1945 with testing in New Mexico, USA, and the subsequent bombings of Hiroshima and Nagasaki. Regardless of attempts to limit the development of nuclear weapons, the current world arsenal has reached the staggering dimensions and presents a significant concern for the biosphere and mankind. In an explosion of a nuclear weapon, over 400 radioactive isotopes are released into the biosphere, 40 of which pose potential dangers including iodine, cesium, alkaline earths, and actinides. The immediate health effects of nuclear explosions include thermal, mechanical, and acute radiation syndrome. Long-term effects include radioactive fallout, internal contamination, and long-term genotoxicity. The current controversial concern over depleted uranium’s somatic and genetic toxicity is still a subject of worldwide sustained research. The host of data generated in the past decades has demonstrated conflicting findings, with the most recent evidence showing that its genotoxicity is greater than previously considered. Of particular concern are the osteotropic properties of uranium isotopes due to their final retention in the crystals of exchangeable and nonexchangeable bone as well as their proximity to pluripotent stem cells. Depleted uranium remains an unresolved issue in both warfare and the search for alternative energy sources.
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References
Walker G. The first atomic test. Trinity Atomic Web Site. 2005. http://www.abomb1.org/trinity/trinity1.html. Accessed 21 Mar 2015.
Malam J. The bombing of Hiroshima: August 6, 1945. Minnesota: Smart Apple Media; 2003.
McNamara R, Blight J. Wilson’s ghost: reducing the risk of conflict, killing and catastrophe in the 21st century. NY: PublicAffairs; 2003.
Kimball D, Davenport K. Nuclear weapons: who has what at a glance: Arms Control Association, Federation of American Scientists, International Panel on Fissile Materials, U.S. Department of Defense, and U.S. Department of State. Updated 2015. http://www.armscontrol.org. Accessed 15 Mar 2015.
Durakovic A. Internal contamination with medically significant radionuclides. In: Conklin J, Walker R, editors. Military radiobiology. Orlando: Academic Press, Inc; 1987.
Vaughan J, Bleaney B, Taylor DM. Distribution, excretion, and effects of plutonium as a bone seeker. In: Hodge HC, Stannard JN, Hursh JB, editors. Handbook of experimental pharmacology—uranium, plutonium, transplutonic elements. Berlin and NY: Springer-Verlag; 1973.
EPA. Radiation protection. Plutonium. Updated 14 Dec 2014. http://www.epa.gov/radiation/radionuclides/plutonium.html#affecthealth. Accessed 13 Mar 2015.
Lloyd RD. Cesium-137 half-times in humans. Health Phys. 1973;25(6):605–12.
Holland JZ. Physical origin and dispersion of radioiodine. Health Phys. 1963;9:1095.
Centers for Disease Control and Prevention. Emergency preparedness and response: acute radiation syndrome. http://emergency.cdc.gov/radiation/ars.asp. Accessed 23 Mar 2015.
Landauer MR. Radiation-induced performance decrement. Mil Med. 2002;167(2 Suppl):128–30.
Bowers G. The combined injury syndrome. In: Conklin, J, Walker R, editors. Military radiobiology. Orlando: Academic Press, Inc; 1987.
Franic Z. Estimation of the Adriatic Sea water turnover time using fallout 90Sr as a radioactive tracer. J Mar Syst. 2005;57(1–2):1–12.
Ramzaev V, et al. Radiocesium fallout in the grasslands on Sakhalin, Kunashir and Shikotan Islands due to Fukushima accident. J Environ Radioact. 2013;118:128–42.
Kozai N, Suzuki S, Aoyagi N, Sakamoto F, Ohnuki T. Radioactive fallout cesium in sewage sludge ash produced after the Fukushima Daiichi nuclear accident. Water Res. 2015;68:616–26.
Bolsunovsky A, Dementyev D. Radioactive contamination of pine (Pinus sylvestris) in Krasnoyarsk (Russia) following fallout from the Fukushima accident. J Environ Radioact. 2014;138:87–91.
Radiation Emergency Medical management. U.S. Department of Health and Human Services. Updated 21 Nov 2014. http://www.remm.nlm.gov/rdd.htm. Accessed 2 Mar 2015.
Cohen, B. The nuclear energy option: an alternative for the 90s. New York: Plenum Press; 1990.
Winter M. Uranium: isotope data. WebElements Ltd, UK. Published 1993. Updated 2015. http://www.webelements.com/uranium/isotopes.html. Accessed 13 Mar 2015.
Morgan Minutes. Published by Busby C on Nov 2014. https://www.scribd.com/doc/245265707/Minutes-of-Meeting-Held-at-AERE-Harwell-9th-July-1953. Accessed 20 Mar 2015.
Guirguis L, Faraq N, Salim A. Accurate fast method with high chemical yield for determination of uranium isotopes (234U, 235U, 238U) in granitic samples using alpha spectroscopy. Nucl Instrum Methods Phys Res Sect A. 2014;777(21):211–7.
Durakovic A. Medical effects of internal contamination with uranium. Croat Med J. 1999;40:49–66.
Zimmerman P. A primer in the art of deception. The cult of the nuclearists, uranium weapons and fraudulent science. New York: Zimmerman; 2009.
Bliese A, Danesi PR, Burkart W. Properties, use and health effects of depleted uranium (DU): a general overview. J Environ Radioact. 2001;64:93–112.
Sarap NB, Jankovic MM, Todorovic DJ, Nikolic JD, Kovacevic MS. Environmental radioactivity in southern Serbia at locations where depleted uranium was used. Arch Ind Hyg Toxicol. 2014;65(2):189.
Busby C. The health effects of exposure to uranium and uranium weapons fallout. Documents of the ECRR 2010, No 2. http://earthlife.org.za/www/wp-content/uploads/2011/04/ECRR-Uranium-and-Health-2010.pdf. Accessed 18 Mar 2016.
Rakovan J, Reeder RJ, Elzinga EJ, Cherniak DJ, Tait DC, Morriss DE. Structural characterization of U(VI) in apatite by X-ray absorption spectroscopy. Environ Sci Technol. 2002;36(14):3114–7.
Peragallo MS, Urbano F, Sarnicola G, Lista F, Veccione A. Cancer incidence in the military: an update. Epidemiol Prev. 2011;35(5–6):339–45.
Sudarevic B, Radoja I, Simunovic D, Kuvezdic H. Trends in testicular germ cell cancer incidence in eastern Croatia. Med Glas (Zenica). 2014;11(1):152–8.
Bogers RP, van Leeuwen FE, Grievnik L, Schouten LJ, Kiemeney LA, Schram-Bijkerk D. Cancer incidence in Dutch Balkan veterans. Cancer Epidemiol. 2013;37(5):550–5.
Strand LA, Martinsen JI, Borud EK. Cancer risk and all-cause mortality among Norwegian military United Nations peacekeepers deployed to Kosovo between 1999 and 2011. Cancer Epidemiol. 2014;38(4):364–8.
Pattison JE. The interaction of natural background gamma radiation with depleted uranium micro-particles in the human body. J Radiol Protoc. 2013;33(1):187–98.
Fathi RA, Matti LY, Al-Salih HS, Godbold D. Environmental pollution by depleted uranium in Iraq with special reference to Mosul and possible effects on cancer and birth defect rates. Med Confl Surviv. 2013;29(1):7–25.
Busby C, Hamdan M, Ariabi E. Cancer, infant mortality and birth sex-ratio in Fallujah, Iraq 2005–2009. Int J Environ Res Public Health. 2010;7(7):2828–37.
Miller AC, Stewart M, Rivas R. Preconceptional paternal exposure to depleted uranium transmission of genetic damage to offspring. Heath Phys. 2010;99(3):371–9.
Xie H, LaCerte C, Thompson WD, Wise JP Sr. Depleted uranium induces neoplastic transformation in human lung epithelial cells. Chem Res Toxicol. 2010;23(2):373–8.
Miller AC, Stewart M, Rivas R. DNA methylation during depleted uranium-induced leukemia. Biochimie. 2009;91(10):1328–30.
Orona NS, Tasat DR. Uranyl nitrate-exposed rat alveolar macrophages cell death: influence of superoxide anion and TNF a mediators. Toxicol Appl Pharmacol. 2012;261(3):309–16.
Al-Hashimi MM, Wang X. Comparing the cancer in Ninawa during three periods (1980–1990, 1991–2000. 2001–2010) using Poisson regression. J Res Med Sci. 2013;18(12):1026–39.
Bakhmutsky M, Squibb K, McDiarmid M, Oliver M, Tucker JD. Long-term exposure to depleted uranium in Gulf War veterans does not induce chromosome aberrations in peripheral blood lymphocytes. Mutat Res Genet Toxicol Environ Mutagen. 2013;737(2):132–9.
Shelleh HH. Depleted uranium. Is it potentially involved in the recent upsurge of malignancies in populations exposed to war dust? Saudi Med. 2012;33(5):483–8.
Briner W, Murray J. Effects of short term and long term depleted uranium exposure in open field behavior and brain lipid oxidation in rats. Neurotoxicol Teratol. 2005;27(1):135–44.
Hao Y, Ren J, Liu J, et al. Immunological changes of chronic oral exposure to depleted uranium in mice. Toxicology. 2013;309:81–90.
Wilson J, Zuniga MC, Yazzie F, Stearns DM. Synergistic cytotoxicity and DNA strand breaks in cells and plasmid DNA exposed to uranyl acetate and ultraviolet radiation. J Appl Toxicol. 2015;35(4):338–49.
Shaki F, Hosseini MJ, Ghazi-Khansari M, Pourahmad J. Toxicity of depleted uranium on isolated rat kidney mitochondria. Biochim Biophys Acta (BBA). 2012;1820(12):1940–50.
Mirderikvand N, et al. Embryo toxic effects of depleted uranium on the morphology of the mouse fetus. Iran J Pharm Res. 2014;13(1):199–206. doi:10.1002/jat.3015.
Canepa C. A model study of the absorbed dose of radiation following respiratory intake of 238U3O8 aerosols. Radiat Prot Dosim. 2014;162(4):515–22.
Valdes M. Estimation of the respiratory tract burden resulting from a prolonged inhalation exposure to aerosols of DU, based on the U in a 24-h urine sample taken years after exposure. Radiat Prot Dosim. 2014;162(4):544–62.
Crean DE, Livens FR, Stennett MC, Grolimund D, Borca CN, Hyatt NC. Microanalytical X-ray imaging of depleted uranium speciation in environmentally aged munitions residues. Environ Sci Technol. 2014;48(3):1467–74. doi:10.1021/es403938d.
Zhu G, Tan M, Li Y, Xiang X, Hu H, Zhao S. Accumulation and distribution of uranium in rats after implantation of depleted uranium fragments. J Radiat Res. 2009;50(3):183–92.
Yousefi H, Najafi A. Assessment of depleted uranium in south-western Iran. J Environ Radioact. 2013;124:160–2.
Parish R, Horstwood M, Arnason JG, Chenery S, Brewer T, Lloyd NS, et al. Depleted uranium contamination by inhalation exposure and its detection after ~20 years: implications for human health assessment. Sci Total Environ. 2008;390(1):58–68.
Jargin SV. Depleted uranium instead of lead in munitions: the lesser evil. J Radiol Prot. 2014;34(1):249–52.
Monleau M, Bussy C, Lestaevel P, Houpert P, Paquet F, Chazel V. Bioaccumulation and behavioral effects of depleted uranium in rates exposed to repeated inhalations. Neurosci Lett. 2005;390(1):31–6. http://www.ncbi.nlm.nih.gov/pubmed/?term=Bioaccumulation+and+behavioral+effects+of+depleted+uranium+in+rates+exposed+to+repeated. Accessed 17 Mar 2016.
Wan B, Fleming JT, Schultz TW, Sayler GS. In vitro immune toxicity of depleted uranium: effects on murine macrophages, CD4+ T cells, and gene expression profiles. Environ Health Perspect. 2006;114(1):85–91.
Baverstock KF. Science, politics, and ethics in the lose dose debate. Med Confl Surviv. 2005;21:88–100.
Carvalho F, Oliveira J. Uranium isotopes in the Balkan’s environment and foods following the use of depleted uranium in the war. Environ Int. 2010;36(4):352–60.
Al-Hadithi T, Al-Diwan JK, Saleh AM, Shabiba NP. Birth defects in Iraq and the plausibility of environmental exposure: a review. Confl Health. 2012;6. doi:10.1186/1752-1505-6-3.
Alaani S, Tafash M, Busby C, Hamdan M, Blaurock-Busch E. Uranium and other contaminants in hair from the parents of children with congenital anomalies in Fallujah, Iraq. Confl Health. 2011;5:15. doi:10.1186/1752-1505-5-15.
Busby C. Very low dose fetal exposure to Chernobyl contamination resulted in increases in infant leukemia in Europe and raises questions about current radiation and risk models. Int J Environ Res Public Health. 2009;6(12):3105–14.
Marshall AC. Gulf War depleted uranium risks. J Expo Sci Environ Epidemiol. 2008;18(1):95–108.
Periyakaruppan A, Kumar F, Sarkar S, Sharma CS, Ramesh GT. Uranium induces oxidative stress in lung epithelial cells. Arch Toxicology. 2007;81(6):389–95.
Schopenhauer A. Aphorismen. Booklassic. 2015[1917]:59 (As translated by author).
Dyer O. WHO suppressed evidence on effects of depleted uranium, expert says. BMJ. 2006;333(7576):990.
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Durakovic, A. Medical effects of internal contamination with actinides: further controversy on depleted uranium and radioactive warfare. Environ Health Prev Med 21, 111–117 (2016). https://doi.org/10.1007/s12199-016-0524-4
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DOI: https://doi.org/10.1007/s12199-016-0524-4