Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure
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The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure.
Materials and methods
The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior–anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25).
Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012).
The results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.
KeywordsSilicosis Bone mineral density Osteoporosis Pneumoconiosis Vitamin D
No funding was received for this article.
Compliance with ethical standards
Conflict of interest
- 2.Pernis B. Silica and the immune system. Acta Biomed. 2005;2:38–44.Google Scholar
- 9.Durham MG. The silicosis and osteoporosis syndrome. In: Robinson NE, Sprayberry KA, editors. Current therapy in equine medicine, 6th ed. Missouri: Elsevier Health Sciences; 2009. p. 303–6.Google Scholar
- 10.Garn H, Friedetzky A, Kirchner A, Jager R, Gemsa D. Experimental silicosis: a shift to a preferential IFN-gamma-based Th1 response in thoracic lymph nodes. Am J Physiol Lung Cell Mol Physiol. 2000;278:1221–30.Google Scholar
- 12.Weitzmann MN. The role of inflammatory cytokines, the RANKL/OPG Axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis. Scientifica (Cairo). 2013;2013:125705.Google Scholar
- 14.International Labour Organization (2011) Guidelines for the use of the ILO International Classification of radiographs of pneumoconioses. Occupational Safety and Health Series. No. 22 (Rev. 2011). International Lavour Office, Geneva.Google Scholar
- 15.World Health Organization. Assessment of osteoporosis at the primary health care level. Summary report of a WHO scientific Group. Geneva: WHO; 2007.Google Scholar
- 16.Kanis JA, On behalf of the World Health Organization Scientific Group (2007) Assessment of osteoporosis at the primary healthcare level. Technical Report. WHO Collaborating Centre, University of Sheffield, Sheffield.Google Scholar