Environmental Health and Preventive Medicine

, Volume 20, Issue 4, pp 287–293

Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice

  • Guangying Qi
  • Xiaoxu Zuo
  • Lihua Zhou
  • Eriko Aoki
  • Aya Okamula
  • Mika Watanebe
  • Haipeng Wang
  • Qiuhui Wu
  • Huiling Lu
  • Handan Tuncel
  • Hiromitsu Watanabe
  • Sien Zeng
  • Fumio Shimamoto
Regular Article

Abstract

Objective

Long-term exposure study was conducted to investigate the effects of extremely low-frequency electromagnetic field on the tumor promotion process and fertility.

Methods

Ten pregnant C57BL/6NCrj mice were exposed to 50 Hz field 500 mG for 1 week (12 h per day), and 24 male and 42 female B6C3F1mice born from them were further exposed up to 15.5 months. As a control group, 10 pregnant mice were bred without exposure, and 30 produced male and 32 female mice were observed without exposure for the same period.

Results

Mean body weights of exposed groups of male and female mice were decreased significantly than those of the control groups. In exposed mice, there was no increased incidence of liver and lung tumor. In female mice, the incidence of chronic myeloid leukemia [3/42 (7 %)] in the exposed group was significantly greater than in the control group. The size of seminiferous tubules in the EMF exposed groups were significantly less than the control group.

Conclusions

These data support the hypothesis that long-term exposure of 50 Hz magnetic fields is a significant risk factor for neoplastic development and fertility in mice.

Keywords

ELF-EMF Long-term exposure Chronic myeloid leukemia Fertility B6C3F1 mice 

Copyright information

© The Japanese Society for Hygiene 2015

Authors and Affiliations

  • Guangying Qi
    • 1
    • 2
  • Xiaoxu Zuo
    • 1
  • Lihua Zhou
    • 1
    • 2
  • Eriko Aoki
    • 2
  • Aya Okamula
    • 2
  • Mika Watanebe
    • 2
  • Haipeng Wang
    • 1
  • Qiuhui Wu
    • 1
  • Huiling Lu
    • 1
  • Handan Tuncel
    • 3
  • Hiromitsu Watanabe
    • 4
  • Sien Zeng
    • 1
  • Fumio Shimamoto
    • 2
  1. 1.Department of Physiopathology and Gastrointestinal SurgeryGuilin Medical UniversityGuilinChina
  2. 2.Department of Health Sciences, Faculty of Human Culture and SciencePrefectural University of HiroshimaHiroshimaJapan
  3. 3.Department of Biophysics, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey
  4. 4.Department of Research Institute for Radiation Biology and MedicineHiroshima UniversityHiroshimaJapan

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